Post-doctoral position available to study the molecular
mechanisms of cell-cell interactions in mammalian development and
disease, using mouse as a model system. We focus on the Hedgehog (Hh)
signaling pathway which is critical for many aspects of embryonic
development, and aberrant regulation of the pathway results in a wide
variety of congenital defects and cancers. The two main areas of
research interest are: (1) The molecular characterization of the
Hedgehog signaling pathway. We wish to understand how the lipidated Hh
ligand generates a morphogen gradient and how the Hh signal is
transduced in Hh-responsive cells; (2) The roles of Hedgehog signaling
in postnatal physiology and homeostasis such as stem cell maintenance
and cancer formation. We investigate regulation of neural and pulmonary
stem cells by Hh signaling and how aberrant Hh signaling leads to brain
tumors and lung cancers. In all of our studies, a combination of mouse
genetics (transgenic and knockout mice), cell biology and biochemistry
are employed.
Please visit our webpage at
http://stemcell.ucsf.edu/about/faculty/chuang
http://tetrad.ucsf.edu/faculty/pao-tien-chuang
for more information.
Please send CV, brief statement of research interests and names of three references to:
Dr. Pao-Tien Chuang Cardiovascular Research Institute University of
California, San Francisco 555 Mission Bay Blvd South, Rm 252F San
Francisco, CA 94158
E-mail: pao-tien.chuang@ucsf.edu
The University of California is an equal opportunity employer