Postdoctoral position in computational biology 2013 - USA

A postdoctoral position in computational biology is available in the lab of Christine Mayr at Memorial Sloan-Kettering Cancer Center in New York City.Our lab is interested in the regulation of gene expression with a focus on alternative polyadenylation (ApA). ApA leads to expression of mRNA isoforms that differ in the length of their 3’UTRs and therefore show differences in post-transcriptional regulation. ApA can also change the C-terminal end of a protein and thus modulate its activity. We use molecular biology methods and computational biology to learn about the regulation and functional consequences of expression of alternative mRNA isoforms generated by ApA in normal and cancer cells. We generate large-scale data sets and integrate transcriptomic and genomic data analyses. We study ApA during aging, cancer pathogenesis and during differentiation of embryonic stem cells.

Requirements:

We are looking for a creative, highly talented and motivated researcher with a PhD in bioinformatics, computer science, machine learning, statistics or molecular biology with exceptional computational skills who is interested in gene regulation. The successful candidate will be an integral part of the lab. The researcher will be involved in developing new ways for analysis of transcriptomic data. Moreover he/she will bring together different large-scale data sets to learn about new ways of gene regulation.

The successful candidate has profound experience in the quantitative analysis of large-scale data sets using R or matlab. The applicant is expected to provide bioinformatics input to experimental design, have quantitative and analytical skills and the ability to work in a team. A strong background in software engineering is a plus. Scientific competence should be demonstrated by publications in high-profile journals.

How to Apply:

Please submit your application including a CV, list of publications, brief research statement and contact information for three references to Christine Mayr (mayrc@mskcc.org).