The WIMM, with its outstanding core
facilities, fosters research in molecular and cell biology with
application to the study of human disease. The project will focus on the
cellular and molecular networks that control the differentiation and
function of thymic epithelial cells. Using novel in vivo models, the
programme seeks in particular to determine the stromal mechanisms
dictating T cell maturation and central tolerance induction.
The planned studies involve molecular
methods of genome- and transcriptome-wide analyses, flow cytometry and
cell sorting, functional cellular assays and other methods. The work
will also comprise the design and generation of novel models to study
thymus biology.
Requirements:You will hold a PhD in
molecular biology, molecular immunology, cell biology or any other area
of biological sciences relevant to the laboratory’s research focus.
Experience with Next Generation Sequencing, epigenomic analyses and
bioinformatics are advantageous. The successful applicants will have
access to a range of state-of-the-art facilities including The Wolfson
Imaging Laboratory. The research group has strong collaborations with
the MRC Functional Genomics Unit in Oxford and several internationally
recognised laboratories both within the UK and abroad.
Contact:
Informal enquiries can be made to: georg.hollander@paediatrics.ox.ac.uk