The lab is situated in a vibrant and highly collaborative multi-disciplinary research environment within the Center for the Study of Inflammatory Bowel Disease (CSIBD) (www.massgeneral.org/csibd/) at the MGH which is currently ranked the nation’s top hospital. This lab benefits from close collaborations on both computational and experimental fronts within the CSIBD and state-of-the-art high-throughput screening and computational platforms at the Broad Institute of MIT & Harvard. Our lab utilizes integrative systems approaches involving computation and high-throughput experimentation (RNA interference (RNAi) and chemical biology screens, transcriptomics, proteomics, metabolomics, and data from genome-wide association studies (GWAS)).
We are seeking creative and highly motivated applicants who have a strong interest in pursuing computational and systems-level research into understanding microbial sensing, biological circuits, networks and pathways in regulating immune responses to microbes or their dysregulation in complex human genetic diseases, including Crohn’s disease, ulcerative colitis and Type I diabetes. This position also provides opportunities to participate in exciting multi-disciplinary research programs investigating the interplay of host genetics and environmental factors (including pathogens and gut microbiota) in influencing immune responses and disease outcomes.
Applicants should have a Ph.D., with a quantitative background in one or more of the following:
• computational biology/bioinformatics,
• computational statistics/physics/mathematics,
• computer science/machine learning/data-mining, or
• engineering/signal processing
Programming proficiency in Java/C/C++, Python/Perl, and MATLAB/R is required. Additionally, prior experience in Next-Generation sequencing (NGS)/RNA-seq analysis, and genome-wide epigenetic profiling, as evidenced by scientific publications in peer-reviewed journals, would be a plus. The successful candidate will be a collaborative individual with the ability to work independently, creatively, resourcefully, meticulously, and also multi-task, support team goals and drive team performance. Excellent written and verbal communication skills are essential.
To apply
Interested applicants should email your CV with contact information of three referees, and a cover letter outlining your career goals to Dr. Aylwin Ng (ang@ccib.mgh.harvard.edu). Expires: May 05, 2013
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