The study is to compare the properties of cortico-subthalamic vs thalamo-subthalamic synapses. We will use patch clamping in brain slices and optogenetics. We already have preliminary results on the basic properties of glutamatergic synapses in the STN using electrical stimulations of the afferent fibers, and also on that of cortico-subthlamic synapses using optical stimulations of ChR2-expressing afferent fibers. The postulant will have i) to implement the transfection of the parafascicular nucleus of the thalamus using stereotaxy ii) decipher the properties of thalamo-subthalamic synapses in vitro iii) examine how subthalamic neurons integrate the synaptic messages from cortex and thalamus.
People with either experience in either in vitro electrophysiology or in vivo recordings + stereotaxy will be welcome.
Marie Curie fellowship (FP7-PEOPLE-2013-CIG) are specific in several aspects, one being that the proposal must to be jointly submitted by the applicant host organisation (i.e. team leader + lab leader + University) and the candidate. Another specificity comes from the eligibility rules.
Contact Information
Dr Taupignon Anne
Institut des Maladies Neurodégénératives
Synaptic and Cellular Dynamics of Neuronal Networks
148 rue Leo Saignat
33076 Bordeaux
France
Phone: (0033)557575764
Fax: (0033)557575760
E-mail: anne.taupignon@u-bordeaux2.fr
Closing date: 2013-05-31
For More Information and to apply