Postdoctoral Position in Computational Structural Genomics - Singapore

We are looking for highly motivated researchers with a strong analytical and computational background and an interest in developing new algorithms for analyzing genome-scale RNA structure datasets. This work will be in collaboration withexperts developing new high-throughput approaches to probe RNA structure genome-wide [1,2] and applying it to study the contribution of RNA structure to various cellular processes.

RNA structure is believed to be fundamental to its function and is important in almost every cellular process [1]. Alterations in RNA structure has also been implicated in several diseases. However the full contribution of RNA structure in biology is still not well understood. Recent developments in genome-wide structure probing methods have resulted in an explosion of RNA structure information [2]. These provide unprecedented detail in probing the structures of most RNAs in the cell and computational approaches to mine such data are still in their infancy. This is an exciting area and analysis of this new type of RNA structure data is likely to yield novel insights into the role of RNA structure and structural alterations in gene regulation, across diverse cellular states and diseases.

References
[1] Wan, Y., Kertesz, M., Spitale, R. C., Segal, E. & Chang, H. Y. Understanding the transcriptome through RNA structure. Nat. Rev. Genet. 12, 641-655 (2011).
[2] Kertesz, M. et al. Genome-wide measurement of RNA secondary structure in yeast. Nature 467, 103-107 (2010). 

Requirements:
- PhD in Computational Biology/Computer Science/Applied Mathematics/Genomics
- Strong analytical and programming skills (C/C++, perl/python, UNIX environment). Candidates with significant experience in RNA structure prediction will be strongly preferred.

Contact:
Genome Institute of Singapore
Niranjan Nagarajan
nagarajann@gis.a-star.edu.sg

Neuroscience Postdoctoral positions 2013 - NTU Singapore

We invite applications for three postdoctoral positions in the Tashiro lab in Warwick-NTU Neuroscience Research Programme at Nanyang Technological University and University of Warwick, located at, Singapore.

Our work mainly focuses on the function of hippocampus circuitry through a multi-disciplinary approach combining virus-mediated genetic manipulation, optogenetic stimulation, behavioral analysis and unit recording techniques in behaving rodents. Our interest focuses particularly on two areas: 1) the function of adult dentate neurogenesis (Ref. Tashiro et al. Nature 442:929-33, 2006. J Neurosci, 27:3252-9, 2007. Aasebø et al., Eur J Neurosci, 33:1094-1100, 2011) and 2) cellular mechanisms underlying place cell activity (ex. Roles of synaptic plasticity or neuromodulatory inputs).Candidates are expected to have strong background in Neuroscience or Engineering, and be capable of independently and cooperatively performing research activities. One position is for molecular/cellular-oriented work, the second one for electrophysiological/behavioral and the third for slice electrophysiology.

To apply, please send C.V. and a description of your research interest to Ayumu Tashiro by email (atashiro@ntu.edu.sg).

Warwick-NTU Neuroscience Research Programme is a newly-established initiative formed by the collaboration between University of Warwick in UK and Nanyang Technological University in Singapore. The programme is located in the Biopolis, a world-class biomedical Research & Development complex in Singapore, organized by Agency for Science, Technology and Research (A*STAR).