USA: Postdoctoral position in translational gene therapy and cell therapy

A Research Associate/postdoctoral position is available in translational gene therapy and cell therapy. This position is available for a scientist (PhD, MD, and/or DVM) interested in the design and use of cell based therapies to modulate immunity for a variety of disease conditions. This position will focus on the development of novel strategies to alter immunity through the use of genetically altered immune cells in the context of cancer, autoimmunity, and/or infection. The overall aim is to develop novel immune therapies, demonstrate efficacy and mechanisms of action in preclinical studies, which will lead to Phase I clinical trials in patients. The ideal candidate will have a background in gene therapy, inflammation, molecular immunity, and in vivo techniques. Experience with autoimmunity, immunotherapy, and viral transduction would be helpful. Good communication skills, leadership potential, and the ability to work in a team are essential. Salary will be commensurate with experience.

To apply: Interested applicants should send a single PDF document by email that contains: a brief summary of research interests and career goals, curriculum vitae, list of publications, and the names of three professional references to:

Dr. Charles Sentman, Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, 6W Borwell Bldg., One Medical Center Drive, Lebanon, N.H. 03756, U.S.A; email: charles.l.sentman@dartmouth.edu; website: http://dms.dartmouth.edu/faculty/facultydb/view.php?uid=139.

London: Postdoctoral Fellowships in Immunity and Cancer

Description
Postdoctoral Fellowships in Immunity and Cancer - POS00121
London-London-London
Full Time
Competitive salary
Closing Date
 - 16/Jul/2013, 12:59:59 AM

Description

About the Job
A postdoctoral position is available at Dinis Calado's Lab at the Cancer Research UK / London Research Institute, in London, United Kingdom. The Lab performs integrative studies on immunology and cancer biology to understand how healthy cells become cancerous, using mainly B-lymphocytes as model system.

Proposed projects aim to:
• Identify and study subpopulations within healthy cells at a particularly high risk of becoming cancer cells, i.e. "cells of origin in cancer".
• Investigate the causative mutations, including the study of non-coding RNAs responsible for cancer development and progression.
• Assess the processes of evasion of cancer cells from immune control by determining the nature of the interplay between a developing cancer and the cells of the immune system.

To address these questions the Lab has in place cutting-edge genetic techniques in vivo in the mouse, and performs mouse I human inter-species comparisons to confirm and/or validate the results obtained in the mouse system.


For more details of the Lab please visit our website http://www.london-research-institute.org.uk/research/dinis-calado  

About you
We welcome applications from candidates with a diverse scientific background. However, knowledge  of  Immunology,  Cancer  Biology,  Genetics,  Molecular  Biology  is  a  plus. Applicants must have a proven publication record from their PhD and/or first postdoctoral position. Postdocs in the Lab are expected to develop and lead projects. Ability to work in a team is essential.





About the London Research Institute
The London Research Institute conducts innovative biological research to improve our understanding of cancer and is internationally recognized for being at the forefront of this field. The institute is committed to training the next generation of research scientists and nearly half of postdoctoral fellows move on to set-up their own research groups. In 2015, the London Research Institute will become part of the new Francis Crick Institute, one of the most significant projects in UK biomedical research in a generation.

To apply
How to apply
To apply, simply click the link below to take you through the Cancer Research UK careers website where you can upload your CV and covering letter.



Postdoctoral Fellowship in Immunity and Cancer
Immunity and Cancer Laboratory
Cancer Research UK I London Research Institute
Full time, 4 years Fixed Term
Competitive salary
Closing date: 16th July 2013

Click Here to apply

Postdoctoral position in tumor biology, Germany

The Institute of Experimental Internal Medicine offers a Postdoctoral position (E13, TV-L)(m/f).

Applicants who have a commitment to scientific excellence as documented by a strong publication record are especially encouraged to apply.

The research program of the institute encompasses scientific projects on the regulation of the NF-kappaB system in the pathophysiology of infection, inflammation and tumor biology (e.g. differentiation and cell cycle control). Here, the molecular and cell biological mechanisms of the intracellular signal transmission are of special interest. The institute allows an internationally competitive research by providing state of the art technologies in protein analysis, mass spectrometry and microscopy.

The institute cooperates with the clinics of the Centre of Internal Medicine in teaching and research and coordinates or participates in a variety of coordinated programs funded by the German Research Foundation (GRK1167, SPP1365, SFB779, SFB854), the Federal Ministry of Education and Research (SysTec) and the European Union (Marie Curie Research Training Network). Further, the institute is member of the interdisciplinaryResearch Center Dynamic Systems: Biosystems Engineering funded by the Federal State of Saxony-Anhalt within the Excellence Program.

The Otto von Guericke University wishes to increase the proportion of female academic personnel. Women are therefore explicitly encouraged to apply. Handicapped persons with equivalent qualification will be given preference.

Please send your application together with the usual documents (CV, list of publications, present and past extramural funding etc.) to: Prof. M. Naumann (naumann@med.ovgu.de). For further information please visit our webpage: http://www.med.uni-magdeburg.de/ieim.html.

Send application to: 
naumann@med.ovgu.de

Prof. Dr. M. Naumann
Institute of Experimental Internal Medicine
Medical Fakulty Otto von Guericke University
Leipziger Str. 44
D-39120 Magdeburg

Postdoc positions in the field of Cancer Biology, Germany

The Institute of Neuropathology at the Justus Liebig University in Giessen, Germany, Director Prof. Till Acker, is inviting applications for
 

2 Postdoc positions:
The microenvironmental control of tumor progression and metastasis

The positions are available immediately.
 
Your profile:
We are looking for enthusiastic and highly motivated applicants holding, or about to obtain, a PhD degree. The applicants should possess a strong research background in molecular and cell biology, experience in cancer research will be an advantage. Preference will be given to applicants with previous experience in one or more of the following areas: protein biochemistry, analysis of signalling pathways, proteomic analysis including analysis of posttranslational modifications, hypoxic signalling, functional genomics or other high-throughput screening methods, epigenetics or in vivo tumor metastasis models.
 
Topic:
Our group has a long-standing interest in the role of microenvironmental factors, particularly hypoxia, hypoxia inducible factors (HIFs) and oxygen sensors of the PHD family, in the regulation of tumor progression and key hallmarks of cancer including angiogenesis, invasion, metastasis, metabolism and differentiation. Our main research interest is to understand the role of microenvironmental sensors and their downstream targets in tumor progression and metastasis.
The proposed projects will aim to dissect the intersection of oxygen sensing pathways with other cellular signalling pathways, including growth factor/RTK and Notch signalling, which are involved in cancer cell proliferation, invasion, metastasis and self-renewal.
 
What we offer:
Our international team offers an open, supportive, dynamic and motivating academic environment with excellent training opportunities. We have won a number of external research grants and are involved in several national and international collaborative projects. We use a wide spectrum of methods: cloning, cell culture, biochemistry, qRT-PCR, FACS, ELISA, cell-based assays (proliferation, apoptosis, migration, 3D invasion, stem cell isolation and cultivation etc.), shRNA screens, proteomics, transactivation assays, virally-based gene delivery and RNAi silencing, immunohistochemistry, in situ hybridization, light, epifluorescence and confocal microscopy, image analysis, animal models and in vivo tumor models.
 
Application:
Please send your applications, including a CV, certificates and references to Dr. Boyan Garvalov
Email: Boyan.Garvalov {at} patho.med.uni-giessen.de;
Please cite reference “Jobvector2013-06”.
 
Website: http://www.ukgm.de/ugm_2/deu/ugi_npa/5424.html
 
Selected references:
Filatova et al, Biochim Biophys Acta 2013, 1830(2):2496-508
Sawamiphak et al, Nature 2010; 465(7297):487-91
Henze et al, Cancer Research 2010;70(1):357-66
Seidel et al, Brain 2010;133(4):983-95
Acker et al, Cancer Cell 2005; 8(2):131-41
Compernolle et al, Nature Medicine 2002; 8(7):702-10

Postdoctoral Positions in Cancer Immunology and virus therapy, United States

POSTDOCTORAL or TECH POSITION is available at the Center for Cell and Gene Therapy, Baylor College of Medicine on NCI/NIH funded projects related to Cancer Immunotherapy and virus therapy. We are seeking candidate who is highly self-motivated and must have a background in vaccinia virus and experience on molecular biology and cell culture. The candidate should possess a Ph.D. or MD. The successful applicant is expected to conduct experiments that include plasmid construction, virus production, cell cultures, immune assays (ELISPOT, CTL assays, and multicolor flow cytometry studies), mice tumor model, under minimal supervision. Excellent opportunities for publication, attendance at scientific meetings, and career advancement.

Interested candidates with experience on vaccinia virus are encouraged to send their curriculum vitae and contact information of references to: Xiao-Tong Song, Ph.D. at xsong1@bcm.edu

Postdoctoral Fellow to study breast and prostate cancer research

We are in search of  junior postdoc for immediate apointment. We have different parellel projects in progress. Major research focus is on mitochondria-nuclear cross talk in cancer.  However we have also other areas interest like, higher order chromatin regulation and nano bioimaging. The lab will utilize interdisciplinary approaches to investigate the epigenetic changes and nuclear-mitochondrial cross talk in cancer. 

Candidate with previous experience in mitochondria or one of the above areas will get preference. Experience in miRNA research will be a strong plus.

Candidate should be interested in breast and prostate cancer research. The candidates are expected to perform independently and work in a collaborative environment.  We use cell and molecular biology, microscopy, flowcytometry, in vivo animal experiments as well as microarray analysis for our projects.

Our lab is located in the Department of Molecular and Human Genetics, Baylor College of Medicine, Houston.  Since Baylor is one of the premier institutes, candidates will be able work with different core facilities and well known research laboratories. Among genetics departments at U.S. medical schools, the department continues to rank high in both grants and funding from NIH. In addition, there are various career development programs available for Baylor postdocs.

Please send your CV with the contact information of three referees to Dr. Benny Kaipparettu, kaippare@bcm.edu

http://www.bcm.edu

Postdoctoral Research position at Cancer Center and Research Institute USA

A Postdoctoral Research position is immediately available in the laboratory of Dr. Jin Q. Cheng at the H. Lee Moffitt Cancer Center and Research Institute. This is an entry-level position for an individual with less than 2 years post-graduate experience in which the individual will be responsible for conducting independent research projects. We are seeking a highly motivated individual to investigate signal transduction pathways and non-coding RNA in human malignancy which could lead to targeted therapies. Candidates should have a Ph.D. degree in Biochemistry/Molecular Biology or a related field. Expertise in cancer signaling, cell cycle and mouse model is highly desirable.

Moffitt Cancer Center is a modern facility on the University of South Florida Campus that conducts research on various aspects of Cancer Biology with emphasis on translational research. The Research environment includes state of the art modern core facilities and pathogen-free modern animal facilities, access to clinical material, etc.

Please apply to position 10943 at www.moffitt.org/careers, and email your CV, a brief summary of research experience and career goals, and contact information for three professional/academic references to jin.cheng@moffitt.org.
 
H. Lee Moffitt Cancer Center & Research Institute is an equal opportunity, affirmative action employer, and a drug free workplace

Post-doctoral Fellowship in Brain tumor stem cells 2013 USA

Post-doctoral fellowship position available at the University of Alabama at Birmingham for candidate interested in brain tumor research related to the characterization of cancer stem cells/brain tumor initiating cells. The cancer stem cell hypothesis posits that a hierarchy exists in some cancers with self-renewing cancer stem cells generating progeny constituting the remainder of the tumor. The presence of highly tumorigenic cancer stem cells has been demonstrated for brain tumors including glioblastoma, the most lethal and prevalent primary malignant brain tumor in adults. Glioblastoma stem cells have been demonstrated to be radio- and chemoresistant as well as highly angiogenic, suggesting the importance of targeting these cells for patient therapies.
We seek to better understand the molecular and biological mechanisms through which brain tumor stem cells drive tumor maintenance in order to identify novel targets for cancer therapy. Applicants should have a Ph.D in Cancer Biology, Molecular Biology, Pharmacology, Neuroscience, or a closely related field.

Candidates must have prior experience with cell culture and molecular biology techniques such as purification of nucleic acids, quantitative real-time PCR, and immunoblotting. Prior experience with production of lentivirus, xenograft models, measurement of DNA repair, immunofluorescence/confocal imaging and/or isolation of primary cells desired. Applicants must be willing to work with human cells and mouse models. Must have strong organizational skills and be detail oriented. Ability to work well independently and apply scientific principles to the solution of novel problems needed. Must work well as part of a team and recognize the benefits of collaboration, taking initiative, and offering constructive criticism.

Chosen candidates will be expected to work with undergraduates and technicians in the laboratory to accomplish experimental goals. In addition to data production, candidates will be expected to communicate findings via the preparation of manuscripts and grants. If interested, e-mail your cover letter, CV, and contact information for three references to Dr. Anita Hjelmeland at hjelmea@uab.edu.

Cancer Biology Postdoctoral Fellowship 2013 - USA

The University of California, Davis, is seeking a post-doctoral fellow to study how the p53 family proteins function as a tumor suppressor and how p53 activity is regulated. In particular, we are interested in examining how the p53 pathway is regulated by microRNAs, translational regulation, and post-translational modifications. The successful applicant will have an opportunity to develop expertise in mouse models of cancer and investigate how the p53 pathway can be altered to control cancer initiation and progression. For more information, please see some of our recent publications (J. Biol. Chem. 287:34410-8; Proc Natl Acad Sci. 109:11300-5; Mol. Cell. Biol. 32: 2336-48; Mol. Cell. Biol. 31:3997-4006; Genes & Dev. 25:1528-43; Proc Natl Acad Sci. 107:9614-9).

We seek a highly motivated individual with a Ph.D. degree in molecular and cellular biology and related fields with 2 years or less of postdoctoral experience. Must have experience in cell culture and molecular biology. Experience in using and handling mice is a plus. Please send your curriculum vitae to Dr. Chen at xbchen@ucdavis.edu. UCD is an Equal Opportunity Employer.

 Application Deadline:     15.7.2013

Postdoctoral Fellow in Cancer Epigenetics 2013 USA

We are seeking for independent, ambitious, and self-motivated candidates for a postdoctoral fellow position to study the epigenetic mechanisms in cancer. The main goal of our laboratory is to develop innovative diagnostic and therapeutic strategies for glioma and other brain cancers.

Responsibility:

On the basis of our prior studies, the candidate will lead projects focused on the BET bromodomain proteins and other epigenetic regulators in glioma. The project will apply molecular, cellular, and bioinformatics tools as well as animal models to develop new epigenetic therapy and design rational drug combinations. There will be ample opportunities to collaborate with other investigators.

Requirements:The candidate is expected to have his/her doctoral degree awarded no more than 5 years ago in a biomedical research-related discipline, and demonstrate a proven track record of high-quality scientific research, as evidenced by publication record and letters of recommendation. Experience in epigenetics, cancer genetics and data mining would be preferred.

How to Apply:

Interested applicants should send a cover letter explaining their research interest and career goals, an updated CV, and contact details for 2 or more referees to jialiang.wang@vanderbilt.edu. Successful candidate will receive salary and benefits commensurate with prior experience and qualifications.

Postdoctoral Associate position at the Duke Cancer Institute USA

An exciting postdoctoral position is available in the Hanks lab at the Duke Cancer Institute. The Hanks Lab's goal is to discover key regulators that induce dendritic cell tolerogenesis in the tumor microenvironment. Toward that goal, we utilize multiple immunologic assays and transgenic mouse models of melanoma. We aim to perform a mechanistic evaluation of identified tolerogenic factors and examine their suitability as therapeutic targets. Duke University offers a highly stimulatory intellectual and collaborative environment for cutting-edge research. A recent PhD is required.  Preference will given to those candidates with prior experience in immunology, mouse tumor models, dendritic cell biology, and cell signaling studies. Please visit our website (http://sites.duke.edu/hankslab/) to learn more about the Hanks lab.  

To apply

Please send your application to hanks004@mc.duke.edu

Postdoctoral Positions in Antibody Engineering 2013 USA

Postdoctoral Positions in Antibody Engineering for the Development of Cancer Therapeutics

Postdoctoral positions are available in the laboratory of Drs. E. Sally Ward and Raimund J. Ober at UT Southwestern Medical Center at Dallas. These positions are supported by recently acquired funds from the Cancer Prevention and Research Institute of Texas (www.cprit.state.tx.us). Post-doctoral appointees will work on projects involving the use of antibody engineering approaches to develop therapeutics for cancer that target growth factor receptors and exposed phosphatidylserine (PS). These studies will use a combination of in vitro and in vivo studies in mice to analyze therapeutic efficacy.

These projects have direct relevance to the rapidly expanding use of antibodies in the biopharma industry.

For more information on the research carried out in the laboratory see www4.utsouthwestern.edu/wardlab or publications such as J. Immunol., 187, 1015, 2011; Proc. Natl. Acad. Sci. USA, 106, 2788-2793, 2009; Traffic, 10, 600-614, 2009; Biophys J., 95, 6025-6043, 2008; Proc. Natl. Acad. Sci. USA, 104, 5889-5894, 2007; Proc. Natl. Acad. Sci. USA, 103, 4457-4462, 2006; Nature Biotechnol., 23, 1283-1288, 2005; Proc. Natl. Acad. Sci. USA, 101, 11076-11081, 2004; J. Immunol., 172, 2021-2029, 2004.

Highly motivated individuals with a Ph.D. in any biological area, (bio)engineering, biotechnology, or chemistry should apply. Relevant experience is desirable but is not essential.

If interested, please send CV and names/addresses of at least three referees to E. Sally Ward at wardlab@utsouthwestern.edu

UT Southwestern is an Equal Opportunity, Affirmative Action Employer.

To apply

If interested, please send CV and names/addresses of at least three referees to E. Sally Ward, Ph.D. at wardlab@utsouthwestern.edu

Biology Postdoctoral positions - Development of Cancer Therapeutics 2013 at USA

Advanced Fluorescence Microscopy for the Development of Cancer Therapeutics

Postdoctoral positions are available in the laboratory of Prof. E. Sally Ward and Prof. Raimund J. Ober at UT Southwestern Medical Center at Dallas. Projects will involve the development and/or implementation of state-of-the-art methods in fluorescence imaging to study the intracellular trafficking of antibodies and growth factor receptors. Imaging methods will include the use of multifocal plane microscopy and superresolution approaches for single molecules/quantum dots to build up three dimensional, dynamic understanding of intracellular processes. These studies have direct relevance to the rapidly expanding use of antibodies in the biopharma industry as therapeutics in cancer and are funded by the Cancer Prevention Research Institute of Texas (www.cprit.state.tx.us).

For more information on the research carried out in the laboratory see www4.utsouthwestern.edu/wardlab, and publications such as Optics Express, 17, 6881-6898, 2009; Biophys J., 95, 6025-6043, 2008; Proc. Natl. Acad. Sci. USA, 104, 5889-5894, 2007; Proc. Natl. Acad. Sci. USA, 103, 4457-4462, 2006; Nature Biotechnol., 23, 1283-1288, 2005; Proc. Natl. Acad. Sci. USA, 101, 11076-11081, 2004; IEEE Transactions Nanobioscience, 3, 237-242, 2004; J. Immunol., 172, 2021-2029, 2004; Biophys. J., 86, 1185-1200, 2004.

Highly motivated individuals with a Ph.D. and background in any biological area, (bio)engineering, biotechnology, chemistry, physics, mathematics or any other physical science will be considered. Direct experience is not necessary. These positions provide an opportunity for the successful candidate to gain experience in advanced microscopic techniques applied to important problems in biotechnology.

For enquiries or to submit an application, please contact E. Sally Ward at wardlab@utsouthwestern.edu

UT Southwestern is an Equal Opportunity, Affirmative Action Employer.

To apply

If interested, please send CV and names/addresses of at least three referees to E. Sally Ward, Ph.D. at wardlab@utsouthwestern.edu

Postdoctoral Position in Functional Cancer Proteomics 2013 USA

A postdoctoral research position in functional cancer proteomics is available in the laboratory of Alex Kentsis at the Sloan-Kettering Institute,Memorial Sloan-Kettering Cancer Center. We carry out research in pediatric oncology and cancer biology, and our current work is focused on the phenomenon of cellular plasticity, as it relates both to the fundamental mechanisms of cancer pathogenesis and emerging rational therapies.

In particular, we are studying the biology of refractory leukemias and pediatric renal tumors, and we are interested in understanding the principles of dysorganization of their genomes and proteomes, and determining the molecular mechanisms of response and adaptation of tumor cells to targeted therapies.

To answer these questions, we are developing new approaches, based on functional genomics and mass spectrometry proteomics, to decipher the mechanisms of genomic plasticity and adaptive signaling.

This post-doctoral research position will leverage an integrated team of researchers using functional genomics and proteomics, dedicated multi-dimensional nanoscale liquid chromatographs and high-resolution mass spectrometers, and dynamic intellectual environment of the SKI. Please see our website for full details of the research project. 

Requirements:

An ideal candidate is a PhD graduate with experience in mass spectrometry and analytical chemistry, who is interested in developing a research programme in functional cancer proteomics. Hands-on experience with the operation of high-resolution mass spectrometers and nanoscale chromatographs, and design of experiments using quantitative proteomics are essential.

For More Information

Postdoctoral Position in Brain Tumor Research 2013 USA

Research lab in the Brain Tumor Research Center at Massachusetts General Hospital is seeking individuals at the postdoctoral level to join an effort dedicated to understanding the human immune response to brain tumors and examining novel immunotherapies in preclinical models. The lab focuses on identification of glioma-associated antigens and in developing immuno-monitoring strategies for patients with cancer vaccination protocols.
The ideal applicant should have a demonstrated track record of first-author publications from graduate work. The applicant must be highly-motivated, able to perform independent experiments, and have a strong background in tumor/xenograft surgical implantation in mouse model systems and in assays of immune function, including ELISA, ELISPOT, and flow cytometry. Molecular biology and histopathology support will be available. Applicants should have a Ph.D. or equivalent. Applications from women and representatives of minority groups are encouraged.
The Massachusetts General Hospital is an equal opportunity employer.
To apply: Interested candidates should forward curriculum vitae, along with names of three references and statement of research interest to: wcurry@partners.org
Department website: http://www.massgeneral.org/neurosurgery/research/researchlab.aspx?id=1465

Postdoctoral Position in Cancer Biology 2013 USA

The Mass General Hospital Cancer Center is a world-renowned institution for cancer biology and translational research. A postdoctoral position is immediately available to study fundamental mechanisms of human tumorigenesis and their application in cancer therapy. Topics of interest include the p53 family of transcription factors, tumor metabolism and signaling through the mTOR kinase pathway, and the influence of tumor-specific genomic changes on tumor evolution and the therapeutic response. Research approaches in the laboratory are uniquely positioned at the interface of biochemistry, cell biology and translational research based on human tumor genetic analysis.

The position involves joint academic appointments at MGH andHarvardMedicalSchool, providing a rich intellectual environment within a large and dynamic research community.

Requirements:

The candidate must have recently (3 years or less) received a Ph.D. degree in the biological sciences, and be highly motivated and well versed in basic molecular biology and biochemical techniques. Previous first-author publication in the English-language literature is essential.Contact:

Please send CV and cover letter to: ellisen@helix.mgh.harvard.edu.

For More Information

Cancer Biology Postdoctoral Fellowship USA 2013

 Seeking a highly motivated postdoctoral applicant to train in an exciting research lab at the Dana Farber Cancer Institute in Boston with a focus on pancreatic cancer biology. The work will focus on understanding various aspects of the disease including its unique metabolism as well as mechanisms of therapeutic resistance and utilizes state-of-the-art mouse models as well as in vitro systems.

Requirements:

Applicant must hold and M.D. or Ph.D. Basic cell and molecular biology experience is required. Experience with mouse models of cancer or techniques to analyze tumor metabolism such as Mass Spec are beneficial.

About us:Located in Boston, Dana Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow’s physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Contact:

Please email CV and Cover Letter to CHIGGINBOTTOM@LROC.HARVARD.EDU
For More Information

Cancer Epigenetics Postdoctoral Position 2013 USA

Constellation Pharmaceuticals is committed to developing cutting edge therapies based on our understanding of how epigenetic mechanisms impact important cellular processes, including transcription, replication and DNA repair in the areas of oncology and inflammation.

Requirements:

We are currently recruiting PhD graduates for postdoctoral positions in cancer epigenetics. Join this unique opportunity to explore chromatin biology and cancer pathways in a translational environment. We have built a strong inter-disciplinary team focused on chromatin therapeutics with expertise in chromatin and cancer biology, bioinformatics, structural biology, and translational medicine. Qualified applicants will have a strong background in oncology and/or chromatin biology, can work collaboratively, and have a track record of publication.

Recent publications include: PNAS 40, 16669-16674 (2011); Science 332, 99-103 (2011); Molecular Cell 28, 665-676 (2007); Cell 129, 915-928 (2007).

How to Apply:

If you are interested in joining Constellation’s team please submit your resume to the following address: careers@constellationpharma.com

For More Information

United States: Postdoctoral position in lung development and cancer biology 2013

    Post-doctoral position available to study the molecular mechanisms of lung development and cancer, using mouse as a model system.  In all of our studies, a combination of mouse genetics (transgenic and knockout mice), cell biology and biochemistry are employed.

    Please visit our webpage at

     http://www.cvri.ucsf.edu/~chuang/index.html

     http://stemcell.ucsf.edu/about/faculty/chuang

     http://tetrad.ucsf.edu/faculty/pao-tien-chuang

    for more information.

    Please send CV, brief statement of research interests and names of three references to:

    Dr. Pao-Tien Chuang Cardiovascular Research Institute University of California, San Francisco 555 Mission Bay Blvd South, Rm 252F San Francisco, CA 94158

    E-mail: pao-tien.chuang@ucsf.edu

    The University of California is an equal opportunity employer

Apply for Postdoctoral Fellow in Tumor Immunology 2013 USA

The Lymphoma Immunotherapy Program at the Mount Sinai School of Medicine has an opening for a Postdoctoral Fellow available in the laboratory of Dr. Joshua Brody, Director.  The position will entail a wide variety of moderately complex responsibilties including  designing protocols and carrying out experiments, interpreting results, and preparing figures to convey analyses for meetings and publication.  Modalities include performing cellular and molecular immunology techniques such as Flow Cytometry, ELISA, Luminex, and studies with animals as well as primary patient specimens.   The lab focuses on basic and applied tumor immunology (particularly in lymphoma, melanoma, and ovarian adenocarcinoma).  Other areas of interest include: bioinformatic-based collaborations tracking T-cell responses using high-throughput sequencing of the entire TCRbV repertoire and studies of small-molecule inhibitors of lymphocyte signal transduction, e.g. PI3K, mTOR, btk.  Our lab has the rare opportunity to both perform correlative studies on primary patient tumor samples from early phase clinical trials and to continually develop advancements in those trials based on what is learned.  The core mission is the translation of basic science in tumor immunology into novel clinical trials, e.g.:

Brody J, et al., In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study. J Clin Oncol. 2010 Oct 1;28(28):4324-32.

Brody J, et al., Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors. Blood. 2009 Jan 1;113(1):85-94.

Brody J, et al., Immunotransplant for mantle cell lymphoma: Phase I/II study preliminary results. J Clin Oncol 29: 2011 (suppl; abstr 2509)

Brody J, et al., Active and passive immunotherapy for lymphoma: proving principles and improving results. J Clin Oncol. 2011 May 10;29(14):1864-75.

REQUIREMENTS:

-PhD in Immunology, Cancer Biology, or related discipline;

-Background experience and expertise in animal studies and flow cytometry.

-Minimum computer skills: Excel, Word, Powerpoint, Flow-Cytometric Analysis software

-Excellent written and verbal communication skills.

To apply

APPLICATION:

1) Cover letter

2) CV

3) 3 recommendation letters or contact information (email & telephone) of 3 references with a brief description of each.

4) citizenship/visa status

All documents should be emailed to:

joshua.brody@mssm.edu

For more information