Postdoc position in Epigenetics and Reproduction, Switzerland

The group of Animal Physiology of the Institute of Agricultural Science at ETH Zürich is offering an open position for a Post-Doctoral Researcher starting September 1st, 2013 in the research area: 

Epigenetics and Reproduction - Maternal Effects on Postnatal Development

The peri-conceptual phase of embryo development is the prelude of life. It is most vulnerable to environmental influences that can impact on health and disease of the individual and further generations. Understanding the epigenetic mechanisms underlying these long-term programming effects is of importance to effectively prevent issues of affluence such as diabetes, obesity and infertility. Considering animal production, these effects can specifically include favorable conditions for postnatal production traits. This research area is linked to the current EU COST Action EPICONCEPT and may be related to effects of endocrine disruption in the developing organism.

Position summary: The main responsibility of this position is to perform basic research in a most fascinating and rapidly emerging field of science in large farm animals. The post-doctoral researcher will head an independent research group and lead a laboratory running molecular analyses of epigenetic modifications, including DNA methylation and chromatin modification. He/she will design and carry out animal experimental programming studies with farm animals (cattle/pigs) in combination with in vitro experiments, apply for project proposals and author manuscripts for publication. The post-doctoral researcher will co-supervise doctoral candidate researchers and MSc students, and contribute to teaching in the field of research.

We are looking for an early experienced, highly motivated young researcher with a strong enthusiasm for scientific work to contribute to our newly establishing research group.

Requirements: Applicants have completed a doctoral degree / PhD in agricultural, animal or nutritional science, biochemistry, biology, or related disciplines. Experience with techniques of molecular biology and epigenetics is required. Candidates have to demonstrate their ability to work in an newly establishing research environment and to publish research results in leading scientific journals. Very good knowledge of spoken and written English is essential.

We offer: A very well equipped facility at ETH Zurich in a workplace of a young and emerging research group will be available. Both collaboration within the Animal Physiology group and outside co-operations are anticipated and highly furthered. Publication activities and conference participations are promoted, and a proper salary is offered.

Applicants should submit a letter of motivation, a detailed CV with copies of certificates, two letters of recommendation/contact details, and scientific publications in a single PDF document to sulbrich@ethz.ch. The selection process starts now and will be continued until the position is filled.

Reproductive Epigenetics Postdoctoral position 2013 - USA

The Division of Reproductive Sciences at Cincinnati Children’s Hospital Medical Center has an opening for a Postdoctoral Fellow. The Namekawa laboratory is focused on elucidating the mechanisms and evolution of epigenetic programming events during germ cell development and early embryonic development. The current goal of the project is to identify novel factors and related pathways that control epigenetic programming during mouse reproduction. The laboratory especially focuses on the events occurring on sex chromosomes in spermatogenesis and epigenetic regulation of spermatogonial stem cells. With this new position, the laboratory would like to explore epigenetic regulation of spermatogonial stem cells. Candidates with a strong background in any of the following areas are encouraged to apply: stem cells, reproduction, epigenetics, spermatogenesis, mouse genetics, bioinformatics, genomics, biochemistry and/or cellular biology. The laboratory is looking for an energetic, highly self-motivated and creative individual who is eager to explore challenging research.

Information about Dr. Namekawa can be found at: http://www.cincinnatichildrens.org/research/div/reproductive-sciences/FacultyandStaff/Faculty/satoshi-namekawa.htm

Recent publications (corresponding author: Satoshi H. Namekawa):
1. Sin HS, Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH. Genes Dev. 2012 Dec 15;26(24):2737-48.
2. Ichijima Y, Sin HS, Namekawa SH. 2012 Cell. Mol. Life. Sci. 2012 Aug;69(15):2559-72.
3. Sin HS, Ichijima Y, Koh E, Namiki M, Namekawa SH. 2012. Genome Res. 2012 May;22(5):827-36.
4. Payer B, Lee JT, Namekawa SH. Hum Genet. 2011, Aug;130(2):265-80.
5. Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH. Genes Dev. 2011 May 1;25(9):959-71.
6. Namekawa SH, Lee JT. Nat Protoc. 2011 Mar;6(3):270-84.

For consideration, please send a CV, a brief statement of scientific/research interests, and contact information for three references to:

Satoshi H. Namekawa, Ph.D.
Cincinnati Children’s Hospital Medical Center
Division of Reproductive Sciences
3333 Burnet Avenue
MLC 7045
Cincinnati, OH 45229
Email: satoshi.namekawa@cchmc.org

To apply online go to http://www.cincinnatichildrens.org/careers/apply/default.htm and search for requisition 64889. Please upload your cv, cover letter, and contact information for 3 references.

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Postdoctoral Fellow in Cancer Epigenetics 2013 USA

We are seeking for independent, ambitious, and self-motivated candidates for a postdoctoral fellow position to study the epigenetic mechanisms in cancer. The main goal of our laboratory is to develop innovative diagnostic and therapeutic strategies for glioma and other brain cancers.

Responsibility:

On the basis of our prior studies, the candidate will lead projects focused on the BET bromodomain proteins and other epigenetic regulators in glioma. The project will apply molecular, cellular, and bioinformatics tools as well as animal models to develop new epigenetic therapy and design rational drug combinations. There will be ample opportunities to collaborate with other investigators.

Requirements:The candidate is expected to have his/her doctoral degree awarded no more than 5 years ago in a biomedical research-related discipline, and demonstrate a proven track record of high-quality scientific research, as evidenced by publication record and letters of recommendation. Experience in epigenetics, cancer genetics and data mining would be preferred.

How to Apply:

Interested applicants should send a cover letter explaining their research interest and career goals, an updated CV, and contact details for 2 or more referees to jialiang.wang@vanderbilt.edu. Successful candidate will receive salary and benefits commensurate with prior experience and qualifications.

Cancer Epigenetics Postdoctoral Position 2013 USA

Constellation Pharmaceuticals is committed to developing cutting edge therapies based on our understanding of how epigenetic mechanisms impact important cellular processes, including transcription, replication and DNA repair in the areas of oncology and inflammation.

Requirements:

We are currently recruiting PhD graduates for postdoctoral positions in cancer epigenetics. Join this unique opportunity to explore chromatin biology and cancer pathways in a translational environment. We have built a strong inter-disciplinary team focused on chromatin therapeutics with expertise in chromatin and cancer biology, bioinformatics, structural biology, and translational medicine. Qualified applicants will have a strong background in oncology and/or chromatin biology, can work collaboratively, and have a track record of publication.

Recent publications include: PNAS 40, 16669-16674 (2011); Science 332, 99-103 (2011); Molecular Cell 28, 665-676 (2007); Cell 129, 915-928 (2007).

How to Apply:

If you are interested in joining Constellation’s team please submit your resume to the following address: careers@constellationpharma.com

For More Information

Postdoctoral Fellow position in Epigenetics and mRNA Splicing 2013 - USA

A post-doctoral position is available to study the relationship between chromatin structure and alternative pre-mRNA splicing. The broad goal will be to examine whether distinct chromatin signatures or DNA methylation impact splice site choice through modulation of RNA polymerase II elongation and/or splicing factor recruitment. These and related questions will be examined in primary lymphocyte cultures, both genome-wide and within the model system of developmentally-regulated CD45 alternative splicing.

Requirements:

Applicants must be strongly motivated, possess a Ph.D. or equivalent and have no more than two years of post-doctoral experience. Individuals with a background in RNA biochemistry, chromatin biology and in vitro differentiation of lymphocytes are especially encouraged to apply. Candidates with experience in bioinformatic analysis of ChIP-seq and RNA-seq data will also be considered. 

How to Apply:

Interested individuals should send a statement of research interests, curriculum vitae including bibliography, and contact information of three references by email to:

Dr. Shalini Oberdoerffer
RNA Processing in Cellular Development
Laboratory of Receptor Biology and Gene Regulation, CCR, NCI
Bethesda, MD
shalini.oberdoerffer@nih.gov

Germany : Postdoctoral position in Epigenetics 2013

The Institute for Anatomy and Cell Biology, Department of Molecular Embryology at the University of Freiburg, Germany is looking for a highly motivated Postdoc in the research group of Prof. Dr. T. Vogel. Our research focus lies on the role of epigenetic histone modifications in neurodevelopment and CNS disease (Büttner et al. PNAS 2010). Within this advertised project we will elucidate the role of histone modifications during development and function of the CNS. Using mouse models we will study histone modifications in the context of the neurological disorders.

We are looking for a highly motivated, scientifically devoted individual with a strong background in Biology, Biochemistry, Biotechnology or related areas, who appreciates a challenging project in Epigenetics in an excellent surrounding (e.g. CRC 992). The successful candidate should have documented experience in techniques of cell biology, protein biochemistry, and molecular biology. Experience with Next-generation-sequencing and analyses of large data sets would be beneficial. We presume very good communication skills in English. The successful candidate will be working within a dynamic, motivated and synergistically acting team.

Employment will be temporary. Interested candidates are invited to send their application including CV, Degrees, References, short letter of motivation, list of publication as PDF-file by email.

Contact Information
Prof. Dr. Tanja Vogel
Albert-Ludwigs-University Freiburg
Molecular Embryology
Albertstr. 17
79104 Freiburg / Breisgau
Germany
Phone:     +49 761 203 5086
Fax:     +49 761 203 5091
E-mail:     tanja.vogel@anat.uni-freiburg.de

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Epigenetics Postdoctoral position 2013 - United States

A postdoctoral position is available at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, in the laboratory of Dr. Shannath Merbs, to study the role of epigenetics in retinal development and ocular diseases such as glaucoma and age-related macular degeneration.  Applicants should be motivated and independent with strong communication and writing skills. Prior experience using epigenetic techniques and/or next gen sequencing is required. Applicants who are no more than 3 years from their doctorate degree and are willing to spend at least 3 years in the lab will be considered with priority. Studies focus on human disease, animal disease models and retinal development. Salary is based on candidate’s experience and current NIH guidelines.

To apply

 Please submit a cover letter, CV and names and contact information for 3 references by email to Tabitha Brewster (tbrewst1@jhu.edu).

Postdoctoral positionto study transcriptional and epigenetic regulation - USA

A postdoctoral position is available to study transcriptional and epigenetic regulation of vertebrate neural development in the laboratory of Kristen L. Kroll at Washington University School of Medicine. We are defining how cells of the early embryo and embryonic stem cells control neural fate acquisition, neural stem and precursor cell maintenance, and neuronal differentiation. We are using genome-wide approaches to define the transcriptional regulatory networks that control neural development and are characterizing how epigenetic regulation modulates these neural gene regulatory networks. We are also assessing how dysregulation of epigenetic activities contributes to malignancy in medulloblastoma and glioblastoma. Biochemical and molecular characterization of essential regulatory molecules is complemented by work in mouse animal models and in mouse and/or human embryonic stem cell, neural stem cell, and other cell-based models. For additional information see: http://devbio.wustl.edu/krolllab/index.html or http://dbbs.wustl.edu/faculty/Pages/faculty_bio.aspx?SID=4039

Setting/Salary/Benefits:
Our laboratory is in an academic setting in the Department of Developmental Biology at Washington University School of Medicine (St. Louis), an internationally recognized research institution with a dynamic research environment and extensive infrastructural and core facility support. Postdoctoral appointees at Washington University receive a starting salary based on the NIH NRSA guidelines and a generous benefit package. Complete information on the benefit package is located on the WUSM Human Resources Benefits Website (http://medschoolhr.wustl.edu). The St. Louis area combines the attractions of a major city with family-friendly and affordable lifestyle opportunities (http://www.stlouis.com/).

Qualifications:
Candidates should hold a recent PhD with less than 2 years of prior post-doctoral experience. Preference will be given to applicants with a strong interest in and research training relevant to the areas of vertebrate neural development, stem cell biology, and transcriptional or epigenetic regulation. US citizens are preferred. Interested candidates should send a CV/names of references by email to kkroll@wustl.edu or by regular mail to Kristen L. Kroll, Washington University School of Medicine, Campus Box 8103, 660 S. Euclid Ave, St. Louis, MO 63110.

Application Deadline: Open Until Filled

Postdoctoral position in Mouse Developmental Neurobiology - 2013 Switzerland

A postdoctoral position is available in the laboratory of Prof. Filippo Rijli at the Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland http://www.fmi.ch/rijli.f. We investigate the epigenetic and transcriptional mechanisms of neuronal migration and topographic circuit formation in the mouse brainstem. Current work is focusing on the involvement of patterning and activity-dependent mechanisms in whisker-to-barrel, auditory, and precerebellar circuit formation. We use spatiotemporally controlled gene targeting, fate mapping of neuronal subpopulations by genetic tools, in utero electroporation, ultrasound-guided microinjection into embryonic brain, trans-synaptic viral tracing of neuronal subsets, as well as molecular phenotype analysis and gene expression profiling.

Outstanding candidates holding a recent PhD and interested in this topic as well as having significant expertise in the above approaches are encouraged to apply. The position is fully funded for 2 years. Nonetheless, ideal candidates are expected to have a strong publication record allowing them to apply for competitive external funding.

Selected references:
Oury et al., Science 313(5792):1408-13, 2006
Geisen et al., PLoS Biol 6(6):e1422008, 2008
Erzurumlu et al., Nat Rev Neurosci 11(4):252-63, 2010
Vitobello et al., Dev Cell 20(4):469-82, 2011
Miguez et al., J Neurosci 32(48):17172-85, 2012
Rhinn et al., J Comp Neurol 521(6):1378-94, 2013
Di Bonito et al., PLoS Genet 9(2):e1003249, 2013
Di Meglio et al., Science 339(6116):204-7, 2013

Applications including a statement of research objectives, a CV, as well as the names and coordinates of three references should be sent by email to:

filippo.rijli@fmi.ch

Prof. Filippo Rijli
Friedrich Miescher Institute for Biomedical Research
Maulbeerstrasse 66
CH-4058 Basel
Switzerland

Postdoctoral Position in Chromatin biology - 2013 Switzerland

A postdoctoral position is available in the laboratory of Prof. Filippo Rijli at the Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland http://www.fmi.ch/rijli.f. We investigate the epigenetic and transcriptional mechanisms of neuronal migration and circuit formation in the mouse brainstem. Current work is focusing on the role of chromatin modifications, non-coding RNAs and chromatin 3D structure in the regulation of key processes, such as neuronal fate specification, migration and connectivity in the mouse.

Outstanding candidates holding a recent PhD and interested in this topic as well as having significant expertise in chromatin biology (ChIP-seq, 4C-seq, FISH) are encouraged to apply. Additional background in bioinformatics, mouse genetics, or developmental neurobiology is a plus. The position is fully funded for 2 years. Nonetheless, ideal candidates are expected to have a strong publication record allowing them to apply for competitive external funding.

Selected references:
Oury et al., Science 313(5792):1408-13, 2006
Geisen et al., PLoS Biol 6(6):e1422008, 2008
Erzurumlu et al., Nat Rev Neurosci 11(4):252-63, 2010
Vitobello et al., Dev Cell 20(4):469-82, 2011
Miguez et al., J Neurosci 32(48):17172-85, 2012
Rhinn et al., J Comp Neurol 521(6):1378-94, 2013
Di Bonito et al., PLoS Genet 9(2):e1003249, 2013
Di Meglio et al., Science 339(6116):204-7, 2013

Applications including a statement of research objectives, a CV, as well as the names and coordinates of three references should be sent by email to:

filippo.rijli@fmi.ch

Prof. Filippo Rijli
Friedrich Miescher Institute for Biomedical Research
Maulbeerstrasse 66
CH-4058 Basel
Switzerland

USA: Postdoctoral Research position - epigenetics/ stem cell research at University of Illinois

The Department of Medicine at the University of Illinois at Chicago is seeking to fill a Postdoctoral Research position in the laboratory of Dr. Joseph DeSimone. Our research focus is on the epigenetic regulation of gene expression during hematopoietic stem cell differentiation. Our aim is to increase the understanding of hemoglobin switching with the goal of developing innovative hemoglobinopathies therapies.
We seek highly qualified, dedicated and highly motivated individuals with a commitment to research excellence and with experience in ChIP and bisulfate sequence analysis and hematopoietic progenitor cell purification from primary bone marrow cells. Research experience in animal models would be an advantage. The candidate should have a pro-active attitude and able to contribute to papers.
Interested applicants should send a cover letter describing their research interests and motivation for the position and a detailed CV (with research experience, scientific and technical skills, publication and conference presentation list, contact information of at least 3 references) to Dr. Joseph DeSimone, University of Illinois @ Chicago, email- jdesimon@uic.edu.

Eligibility criteria:
- PhD/MD or PhD will have been awarded by start date
- At least one publication in an inter-disciplinary or specialized peer-reviewed journal
UIC is an AA/EOE. Women and Minorities are encouraged to apply.