Postdoctoral position cell signalling 2013, Germany

A PhD position and a postdoctoral position are available in project 1 (Feil) of the newly established DFG Research Unit FOR 2060. Project start is summer 2013. The Research Unit investigates the function of the intracellular signalling molecule, cyclic guanosine monophosphate (cGMP) in mammals, specifically in tissue degeneration and regeneration. Project 1 studies the role of global and local cGMP signals in growth control. We use fluorescence-based cGMP sensor proteins to visualize changes of the signalling molecule in living cells in real time. This will allow us to monitor the spatiotemporal dynamics of cGMP signalling under various conditions and to correlate the respective cGMP signals with associated alterations in the growth of cardiovascular and neuronal cells. The projects involve analyses at the molecular, cellular and whole organism level. Candidates should be interested to work at the interface of biochemistry and biomedicine, with a focus on cell signalling under native conditions. Experience in the fields of signal transduction, transgenic mouse technology, and/or live cell imaging would be an advantage.

For recent project-relevant publications of our group, see:
Original Article: Thunemann, Wen et al. (2013). Transgenic mice for cGMP imaging. Circ Res, in press.
Methods Article: Thunemann et al. (2013). Visualization of cGMP with cGi biosensors. Methods Mol Biol 1020, 89-120.
Review Article: Kemp-Harper & Feil (2008). Meeting report: cGMP matters. Sci Signal 1, pe12.

For further information, please visit www.cyclic-gmp.de or www.ifib.uni-tuebingen.de/forschung/feil.html.

Please send your application (including names/emails of 2 referees) to Prof. Dr. Robert Feil, University of Tübingen, Interfakultäres Insitut für Biochemie (robert.feil@uni-tuebingen.de).

Deadline for applications: 16 August 2013

Postdoctoral position in cardiovascular diseases 2013, Spain

Applicants must be experienced researchers with a doctoral degree related to medical/biological sciences and interest in cardiovascular diseases. Applicants must possess a strong publication record, with experience in molecular biology, cell biology and signaling.  Experience with animal models of regeneration and hematopoietic/cardiac stem cells is preferable.

We offer a 2 year contract with competitive salary according to the experience of the selected candidate. The CNIC has an advanced policy on matters of welfare benefits, with the most modern flexible remuneration systems.

To apply
Qualified applicants should submit an application by e-mail, including a letter outlining research interests, a CV, and the contact information of three referees, to Eduardo Bieger (ebieger@cnic.es)

http://www.cnic.es/en/inflamacion/metaloproteinasas/index.php

Postdoctoral position to study Epithelial Cell Biology 2013 USA

Postdoctoral position available for a fellow with an interest in Epithelial Cell Biology (New York University School of Medicine).

The laboratory is studying the cell biology of the urinary bladder urothelium. The research focuses on the molecular mechanisms of the synthesis and subcellular trafficking of uroplakins. It is supported by an NIH Program Project grant that includes a team of five investigators (Michael Rindler, PhD and Gert Kreibich, membrane biogenesis; Tung-Tien Sun, PhD, urothelial biology and stem cells; Xiangpeng Kong, PhD, atomic structure of membrane proteins; and Xue-Ru Wu, MD, urinary tract infection). Thus the group offers excellent exposure to multiple disciplines and collaborative opportunities that have led to the discovery that uroplakins play a key role in urothelial barrier function, the establishment of mouse transgenic and gene knockout models for studying uroplakin traffic, and the demonstration that uroplakins are the major receptors for uropathogenic E. coli causing urinary tract infection.

Please send a cover letter, CV and contact information for three references to michael.rindler@nyumc.org

Michael Rindler, Ph.D.
Associate Professor
Department of Cell Biology
New York University School of Medicine
Alexandria Center for Life Sciences
450 East 29th St, Room 826
New York, NY 10016
Tel: 212-263-5812
FAX: 212-263-5100

NYU is an equal opportunity employer

Postdoctoral Research position at Cancer Center and Research Institute USA

A Postdoctoral Research position is immediately available in the laboratory of Dr. Jin Q. Cheng at the H. Lee Moffitt Cancer Center and Research Institute. This is an entry-level position for an individual with less than 2 years post-graduate experience in which the individual will be responsible for conducting independent research projects. We are seeking a highly motivated individual to investigate signal transduction pathways and non-coding RNA in human malignancy which could lead to targeted therapies. Candidates should have a Ph.D. degree in Biochemistry/Molecular Biology or a related field. Expertise in cancer signaling, cell cycle and mouse model is highly desirable.

Moffitt Cancer Center is a modern facility on the University of South Florida Campus that conducts research on various aspects of Cancer Biology with emphasis on translational research. The Research environment includes state of the art modern core facilities and pathogen-free modern animal facilities, access to clinical material, etc.

Please apply to position 10943 at www.moffitt.org/careers, and email your CV, a brief summary of research experience and career goals, and contact information for three professional/academic references to jin.cheng@moffitt.org.
 
H. Lee Moffitt Cancer Center & Research Institute is an equal opportunity, affirmative action employer, and a drug free workplace

Cell Biology Postdoc position 2013 United States

A post-doctoral position is available to study the roles of ubiquitination in G protein-couled receptor (GPCR) signaling.    My group is interested in identifying novel mechanisms of GPCR regulation and signal transduction. This includes pathways involving beta-arrestins and arrestin-domain containing proteins. We employ a wide range of techniques ranging from in vitro assays to animal models.

Requirements: 

Candidate who is highly motivated and shares a vision of excellence and commitment to research with a recent PhD in Pharmacology, Cell Biology or related discipline is preferred. Prior experience with mouse models is also preferred.

Candidate should have less than two years of post-doc experience.

Candidate must be legally authorized to work in the US.

To apply

Submit CV and names/contact information of three references to Sudha K. Shenoy via email:
sudha@receptor-biol.duke.edu

For More Information

Cancer Biology Postdoctoral fellow position 2013 - Baltimore USA

A postdoctoral fellow position is available immediately to study signal transduction by protein kinases and nuclear receptors in metastasis and drug resistance of human cancer cells (References: Cancer Cell, 10:309-319; Cancer Cell, 15: 270-282; Cancer Research, 69: 2305-13; Cancer Research, 70, 5587-5596; J. Biol. Chem., 283:3349-56; 286:36152-60).
Highly motivated and recently graduated (within last 3 years) individuals with experience in molecular biology, biochemistry, cancer biology and animal models are encouraged to apply. Send CV and the names of three references to:


Dr. Yun Qiu
Department of Pharmacology
University of Maryland School of Medicine
655 W Baltimore St,
Baltimore, MD 21201
Email: yqiu001@umaryland.edu

Application Deadline: Open Until Filled 


For further information about the research projects, please refer to
http://medschool.umaryland.edu/facultyresearchprofile/viewprofile.aspx?id=6948.

Postdoc position in Signal Transduction and Growth Control - 2013 at Germany

Chronic inflammation is a main driver of the development of hepatocellular carcinoma (HCC), one of the most frequent and dismal human malignancies. Employing mouse models of inflammation-driven cancer including squamous cell carcinoma and HCC, our Division has identified the damage molecular pattern (DAMP) molecules S100A8/A9 and HMGB1, as well as the receptor RAGE as important players of chronic inflammation and cancer development (Hummerich et al., 2006, Oncogene 25:111-21; Gebhardt et al., 2008, J Exp Med 205:275-85; Nemeth et al., 2009, Hepatology 50:1251-62; Wiechert et al., 2012, Cell Comm Signal, 10:40; Pusterla et al., 2013, Hepatology, in press). The current project aims at analysing the function of S100A8/A9 and HMGB1, as well as the receptor RAGE in hepatocellular cancer and metastasis. In addition, the impact of these molecules in the link between cancer and metabolism will be explored. The candidate will apply gain-of-function and loss-of-function approaches in genetically modified mice and in vitro cell cultures to define the role of these molecules in chronic liver damage, inflammation, tumor cell formation and invasion using state-of-the-art transgenic and shRNA/ siRNA technologies.

Your Profile:
We are looking for a highly motivated and ambitious Postdoc with a Ph.D. to complement our team. The candidate should have a strong background in molecular and cellular biology demonstrated by peer-reviewed publications and a strong interest in liver tumor biology. Excellent experimental and analytical skills in advanced cell culture techniques and mouse genetics including animal experimentation are mandatory.

http://www.dkfz.de/en/stellenangebote/index.php?id=049/2013

Post-doctoral Scientist position 2013 at The MRC Laboratory of Molecular Biology

Post-doctoral Scientist – 3 Year Fixed Term
Starting Salary £26,282 to £28,083 per annum
Band Salary £26,282 to £37,040per annum

Currently in our Centenary year, The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably X-ray crystallography of proteins, DNA sequencing and monoclonal antibodies.

With the opening of our new laboratory the LMB provides an unsurpassed environment for both young and established researchers. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.

The purpose of the role will be to work within a programme aimed at studying AMPA receptor signalling in neuronal cultures and slices. Specifically, to investigate AMPAR subunit remodelling and dendritic targeting in hippocampus in response to altered neuronal activity and the role of RNA editing therein. In addition to brain slice electrophysiology this project involves confocal microscopy and transgenic mice. For more information please contact I Greger (ig@mrc-lmb.cam.ac.uk), and Penn and Greger (2009), RNA Biol; Penn et al Neuron (2012); Balik et al Nucleic Acids Res (2013).c

Candidates should have a PhD in a biological or biophysical subject and good experience with electrophysiological recordings. Experience with brain-slice recordings would be advantageous. A basic knowledge of standard molecular biology techniques or confocal microscopy would be desirable. For more information please contact Dr. I. Greger: ig@mrc-lmb.cam.ac.uk

Successful applicants will be awarded a three-year Career Development Fellowship. The fellowship is a training and development position for a post-doctoral scientist who has recently completed their doctoral studies, and is moving into a new research discipline.

Your salary will be supported by 30 days annual leave entitlement, an optional MRC final salary pension scheme and excellent on-site sports and social facilities.

Applications are handled by the RCUK Shared Services Centre; to apply please visit our job board at http://www.topcareer.jobs/Vacancy/irc89370_2935.aspx and submit your CV along with a Cover Letter quoting the IRC number. If you are unable to apply online please contact us on 01793 867003 quoting reference IRC89370.

Closing date: 5 May 2013

Final appointments will be subject to a pre employment screening
The Medical Research Council is an Equal Opportunities Employer"

Postdoc position in Cell Biology 2013 at Switzerland

Empa
Esther Zürcher
Human Resources
Lerchenfeldstrasse 5
9014 St. Gallen
Switzerland
www.empa.ch  

Empa is the interdisciplinary research and services institution for material sciences and technology development of the ETH Domain.
The Laboratory for Materials-Biology Interactions in St. Gallen offers a
PostDoc position in the field of Material-Cell-Interface Research
 
The activities of the Postdoc position are focused on cell biology in context with mainly graphene based nanomaterials. To achieve new insides in their biological effects, in vitro studies are a pre-requisite to evaluate the biological effects of these materials. The candidate will develop and optimize advanced in vitro assays and use those for assessing the underlying molecular mechanism in order to support a safe and sustainable use of graphene based applications.


The candidate is expected to work with different cell types, including class II primary human cells.
The candidate should have a PhD degree in Biology, Bioengineering, or related disciplines. We are looking for a highly motivated person capable of independent, efficient handling of scientific and industrial related projects in an interdisciplinary environment. The candidate is expected to actively bring in his/her scientific expertise and competence. Experience in cell biology and molecular biology are highly desired. Good skills in general biology, genetic engineering and biochemistry are of advantage. The position (100%) will be limited to two and a half years with options for an extension.

The candidate should to be fluent in English and preferably has agood knowledge of German.

For further information please contact Dr. Peter Wick, phone +41 58 765 7864 e-mail: peter.wick@empa.ch. Applications should include a CV, a list of publications, letter of motivation and addresses of two referees.
Please submit your application online and upload all documents ("pdf"-file is recommended) through this webpage. Any other way of applying will not be considered.

https://sv1.refline.ch/673276/0352/index.html?cid=9&lang=en

USA: Postdoctoral Fellowship in molecular biology/ cell biology at The University of Texas MD Anderson Cancer Center

Multiple positions open for Postdoctoral Fellows. Should have experience in molecular biology, cell biology and possess knowledge of cancer biology. Having expertise in Bioinformatics is a big plus. High motivation and being able to work independently are absolutely required.

Two Projects:
(1) Characterizing and Targeting CHD4 Deficiency in Endometrial Cancer (positions available immediately).
(2) Studying How Tyrosine Phosphorylation Links to Protein Stability in Breast Tumor Suppression (positions open from March 1st).


Shiaw-Yih Lin, Ph.D.
Associate Professor, Tenured
The University of Texas MD Anderson Cancer Center
Department of Systems Biology, Unit 950
South Campus Research Building II
P. O. Box 301429
Houston, TX 77230-1429
E-mail: sylin@mdanderson.org



MD Anderson Cancer Center is an equal opportunity employer and does not discriminate on the basis of race, color, national origin, gender, sexual orientation, age, religion, disability, or veteran status except where such distinction is required by law. All positions at The University of Texas MD Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment.

Germany:Postgraduate Research Associate post at BioMed X Innovation Center

About BioMed X

The BioMed X Innovation Center constitutes a novel way of collaboration at the interface between academia and industry. Young life science talents from all over the world will be working jointly on pre-clinical research topics in the fields of biomedicine, molecular biology, cell biology and chemoinformatics. Interdisciplinary project teams are collaborating in an open-innovation lab facility on the campus of the University of Heidelberg, with guidance of experienced mentors while expanding their scientific network and receiving an intensive entrepreneurship and leadership training.


What we are looking for

Applications are invited from outstanding early-career scientists working or interested in one of the following fields of research:


1. Cancer & Inflammation:

The immunosuppressive microenvironment of tumors applying methods for the identification of new targets for immunotherapy of cancer
2. Metabolism & Signaling in Cancer:

Cross-talk between signaling and metabolism in cancer and identification of new metabolic targets for cancer therapy
3. Selective Kinase Inhibitors:

Computational and/or knowledge-based models for prediction of kinase specificity and development of software for the identification and design of novel selective kinase inhibitors or inhibitors of other large target classes


What we offer

Six postgraduate research associate positions are offered for an initial term of two years, with the possibility of prolongation for up to two additional years, and an option for a permanent position. The positions are intended to suit those with typically up to four years postgraduate research experience who would, once established, be in a strong position to enter a research management career path either in academia or industry. The positions include generous funding packages covering personal salary and consumables, as well as access to the core facilities of neighboring research institutions and biotechnology companies. There is flexibility over starting dates, but successful applicants are anticipated to take up post by July 1, 2013.


Application & Selection Process

Applications are to be made online at http://www.bio.mx.

Only applications received before Sunday April 7, 2013 will be considered. As part of the online application procedure candidates will be required to upload a CV, provide supporting statements and project proposals.

After a first selection round, candidates will be invited to a five-day assessment center workshop in Heidelberg. The invitation includes full coverage of travel expenses, accommodation, sightseeing, and food for the entire workshop which will take place from April 29 to May 3, 2013. With guidance of experienced mentors, candidates will jointly work on their project proposals and present them in front of a jury on the final day. Successful candidates will be offered a position at the BioMed X Innovation Center.

Germany: Postdoctoral Researcher position at BioMed X Innovation Center

About BioMed X

The BioMed X Innovation Center constitutes a novel way of collaboration at the interface between academia and industry. Young life science talents from all over the world will be working jointly on pre-clinical research topics in the fields of biomedicine, molecular biology, cell biology and chemoinformatics. Interdisciplinary project teams are collaborating in an open-innovation lab facility on the campus of the University of Heidelberg, with guidance of experienced mentors while expanding their scientific network and receiving an intensive entrepreneurship and leadership training.


What we are looking for

Applications are invited from outstanding early-career scientists working or interested in one of the following fields of research:


1. Cancer & Inflammation:

The immunosuppressive microenvironment of tumors applying methods for the identification of new targets for immunotherapy of cancer
2. Metabolism & Signaling in Cancer:

Cross-talk between signaling and metabolism in cancer and identification of new metabolic targets for cancer therapy
3. Selective Kinase Inhibitors:

Computational and/or knowledge-based models for prediction of kinase specificity and development of software for the identification and design of novel selective kinase inhibitors or inhibitors of other large target classes


What we offer

Eight postdoctoral researcher positions are offered for an initial term of two years, with the possibility of prolongation for up to two additional years, and an option for a permanent position. The positions are intended to suit those with typically up to four years postdoctoral experience who would, once established, be in a strong position to enter a research group leader career path either in academia or industry. The positions include generous funding packages covering personal salary and consumables, as well as access to the core facilities of neighboring research institutions and biotechnology companies. There is flexibility over starting dates, but successful applicants are anticipated to take up post by July 1, 2013.


Application & Selection Process

Applications are to be made online at http://www.bio.mx.

Only applications received before Sunday April 7, 2013 will be considered. As part of the online application procedure candidates will be required to upload a CV, provide supporting statements and project proposals.

After a first selection round, candidates will be invited to a five-day assessment center workshop in Heidelberg. The invitation includes full coverage of travel expenses, accommodation, sightseeing, and food for the entire workshop which will take place from April 29 to May 3, 2013. With guidance of experienced mentors, candidates will jointly work on their project proposals and present them in front of a jury on the final day. Successful candidates will be offered a position at the BioMed X Innovation Center.