Post-Doctoral Position in Protein Crystallography at Germany

Proteros Biostructures is Europe s most experienced and largest biotechnology company in the field of X-ray protein structure analysis and a leading service partner for fully integrated lead discovery. Successful in business since 1998, Proteros collaborates with more than 80 international pharma, biotech and agricultural companies. To support our crystallography team in Martinsried/Munich we are looking for a

Post-Doctoral Position in Protein Crystallography (m/f)

A postdoctoral position is available at Proteros in Martinsried

• The subject of the project will be the structure determination of a therapeutic target of considerable interest
• You will handle construct design, cloning, protein expression (E.coli, Bacculo or Mammalian), Purification and set up of activity assays
• You will conduct all crystallographic activities of protein structure determination:
• X-ray diffraction data collection (in-house generators and synchrotron beamlines)
• X-ray diffraction data processing, experimental phasing and MR
• model building and refinement

The ideal candidate will meet the following requirements:

• You have a degree in Chemistry/Biochemstry/Biology or a related field and a Ph.D. in X ray protein crystallography with excellent track record
• strong experience in molecular biology (cloning), protein production
• PDB-depositions and related publications
• Ideally you have good knowledge of LINUX systems and acquaintance with current software packages employed in protein crystallography.
• You have excellent communication skills and like to work in a multi-disciplinary team

Are you interested?
We are looking forward to your application. In case you have further questions
with regard to this offer please contact us: ++49-89-700 761 0.
Please apply by sending your full application documents to:
Proteros Biostructures GmbH | Mrs Cornelia Bluhm | Bunsenstr. 7a | 82152 Martinsried or electronically to: bewerbung@proteros.de

Post-Doctoral position Epigenetic drug discovery 2014 at GlaxoSmithKline

GlaxoSmithKline is a science-led global healthcare company that researches and develops a broad range of innovative medicines and brands. We have a challenging and inspiring mission: to improve the quality of human life by enabling people to do more, feel better and live longer. This mission gives us the purpose to develop innovative medicines and products that help millions of people around the world. As a company, we also believe in developing talent and people. At GSK, you have the opportunity to make a real contribution in a dynamic and diverse business environment.

Cellzome, a GSK company, based in Heidelberg, applies its world-class proteomics technology to the discovery of safe and effi cacious drugs.

At our site on the EMBL campus in Heidelberg, Germany, we have an opening for a full time

2 years Post-Doctoral position (f/m)
(Start January 1^st 2014)

Position:The successful candidate will work on Epigenetic drug discovery. In particular, the focus of the work will be drug target validation and mode of actions of compounds targeting epigenetic factors. She/he will set strategies for studies, implement new methods and combine them with cutting edge chemoproteomic technologies. The position requires work in a multi-disciplinary team and the ability to interact with groups across different lines, GSK sites and academic labs.

Requirements:Recent PhD in biology or biochemistry (0-2 years post-doctoral experience). A background in epigenetic and chromatin biology including familiarity and experience with concepts and broad based epigenetic technologies (i.e. Chip) will be advantageous.

We are looking for a motivated individual with the potential to make a strong impact in novel drug discovery projects in the fi eld of Epigenetics. Flexibility and the ability to work in a team focused on innovative drug discovery are essential. Communication skills and experience in presenting data are important.

Cellzome provides a high quality, international research environment with world-class proteomics capabilities. For a fi rst introduction to Cellzome, please refer to some of recent publications (e.g. Bantscheff, Nat Biotech 2011, Dawson et al., Nature 2011, Bergamini, Nat Chem Biol 2012).

If you want to make a real difference to people’s lives across the globe – and your own career prospects in the process – find out more at www.gsk.com and apply now.

Applicants should send their CV summarizing qualifi cations and experience, including the names and addresses of two referees, no later than 30th November 2013.

https://careers.peopleclick.com/careerscp/client_gsk/external1931/jobDetails.do?functionName=getJobDetail&jobPostId=217518&localeCode=en-us

Industrial Post doc in Biochemistry position 2013 USA

PMC Advanced Technologies, a division of PMC Group, Inc is seeking an industry postdoctoral fellow in experimental biochemistry for its R&D laboratories in Mt. Laurel, New Jersey. 

Responsibilities

·        Solid background in biology, biochemistry, and conjugation chemistry.

·        Develop of fluorescent probes suitable for clinical imaging studies

·        Hands on experience with the operation, application, and interpretation of chemical and biochemical conjugation, cross-linking, in-gel fluorescence, chemical modification of proteins, protein assays, recombinant protein and peptide chemistry etc.

·        Familiarity with operation of state of the art laboratory instruments and applicable software.

·        Effective analytical and problem solving skills

Apply online : recruiter@pmc-group.com

Qualifications
Ph.D. degree in Chemical/Biochemical Engineering, Biochemistry.

To apply

online recruiter@pmc-group.com

Industrial Postdoctoral Position for biochemist/ biophysicist/ crystallographer at AstraZeneca, USA

We have an exciting opportunity for a biochemist/biophysicist/crystallographer to join the Structure & Biophysics group at AstraZeneca in Waltham, MA. This is a collaborative effort with the laboratory of Professor Jamie Cate at the University of California Berkeley to understand the structural basis of mechanism-based toxicity to antibiotic treatment. Success in generating chimeric ribosomes will result in novel means to assess antibacterial sensitivity using a suite of genetic, biochemical and biophysical approaches.

This position provides an opportunity to explore the gene-to-structure process in an industrial setting. You'll be exposed to a variety of aspects within the drug discovery cascade, and will interact with scientists in a cross-disciplinary environment. You'll also be expected to deliver your novel research results within AstraZeneca, and externally via scientific conferences and peer-reviewed publications.

Your major responsibilities


* Build an understanding of antibiotic selectivity for the bacterial ribosome through the design and analysis of the functional activity of chimeric ribosomes
* Assess the antibacterial sensitivity of recombinant bacterial strains containing chimeric ribosomes against a panel of known ribosomal inhibitors
* Understand the structural basis of ribosomal inhibitor selectivity by performing crystallography on chimeric ribosomes in complex with antibiotics
* Work collaboratively with scientists across various disciplines to achieve project objectives
* Externally present results at scientific conferences, and publish scientific papers in high quality peer-reviewed journals


Minimum experience

A PhD in one or more of the following areas:


* Protein/RNA biochemistry
* Biophysics, crystallography, ribosome biology, molecular microbiology


Preferred experience/requirements


* Molecular biology, expression and purification skills to independently produce high-quality RNA-protein complexes
* Experience with multiple biochemical and biophysical techniques to assess the quality, stability and function of RNA-protein complexes
* Experience in performing antibacterial sensitivity assays
* Experience in designing complex reagents for biophysical and crystallographic studies
* Crystallographic experience is highly desirable
* Strong written and oral communication skills

Apply Now

Industrial Postdoc Position in drug discovery at AstraZeneca, Sweden

Location: Mölndal, Sweden

AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

Right now we have an exciting opportunity for a Ph.D. scientist to develop methodology that determines the orientation of ligands bound to proteins of pharmaceutical interest. The aim of the work is to produce information that is complementary to conventional methods for structure determination of protein-ligand complexes and enable more efficient synthetic chemistry efforts in a drug discovery programme. The work is multi-disciplinary in nature and includes secondments to Leiden University and the University of Florence, research centres with extensive experience in paramagnetic protein NMR.

This position is part of the FP7 – PEOPLE Marie Curie Initial Training Network "pNMR" (Pushing the Envelope of Nuclear Magnetic Resonance Spectroscopy for Paramagnetic Systems. A Combined Experimental and Theoretical Approach). For more information please visit http://www.pnmr.eu/.

Objectives
• To enable more efficient synthetic chemistry efforts in drug discovery by determining the relative orientation of small molecule ligands to at least one drug target protein.
• To show that this can be achieved within a time-frame that is compatible with the time-lines in a drug-discovery programme.

Responsibilities
• Show strong initiative in conducting research, and bringing it to functional use within AstraZeneca and the drug discovery community.
• Interface with scientists from across many disciplines while at the same time being able to work independently.
• Strong written and oral communication skills.
• Ability to work effectively with colleagues and initiate collaboration.

Tasks and methodology
• Production of drug target protein with lanthanide binding tags rigidly attached.
• Determination of pseudo-contact shift (PCS) tensors for the lanthanide tagged proteins.
• Detection of transferred PCSs for several ligands.
• Structure calculations based on PCSs. Comparison with known crystal structures to assess quality of PCS-based structures.

Minimum experience
• A PhD in biomolecular NMR or closely related field.

Preferred experience/requirements
• Protein NMR assignments.
• Protein-ligand interactions and binding kinetics.
• Protein production.
• Paramagnetic NMR.
• Synthetic chemistry.

AstraZeneca – Health Connects Us All
As one of the world's leading pharmaceutical companies, our business is focused on providing innovative, effective medicines that make a real difference in important areas of healthcare. What’s more, we support and encourage our people in discovering their own potential. Excellent learning and development opportunities will be available to you throughout your career here.

Contact:
For more information about the position please contact Tomas Åkerud at +46 31 7064412

Please send your application no later than April 30, 2013

AstraZeneca welcomes applications from all sections of the community.

http://jobs.astrazeneca.com/jobs

Germany:Postgraduate Research Associate post at BioMed X Innovation Center

About BioMed X

The BioMed X Innovation Center constitutes a novel way of collaboration at the interface between academia and industry. Young life science talents from all over the world will be working jointly on pre-clinical research topics in the fields of biomedicine, molecular biology, cell biology and chemoinformatics. Interdisciplinary project teams are collaborating in an open-innovation lab facility on the campus of the University of Heidelberg, with guidance of experienced mentors while expanding their scientific network and receiving an intensive entrepreneurship and leadership training.


What we are looking for

Applications are invited from outstanding early-career scientists working or interested in one of the following fields of research:


1. Cancer & Inflammation:

The immunosuppressive microenvironment of tumors applying methods for the identification of new targets for immunotherapy of cancer
2. Metabolism & Signaling in Cancer:

Cross-talk between signaling and metabolism in cancer and identification of new metabolic targets for cancer therapy
3. Selective Kinase Inhibitors:

Computational and/or knowledge-based models for prediction of kinase specificity and development of software for the identification and design of novel selective kinase inhibitors or inhibitors of other large target classes


What we offer

Six postgraduate research associate positions are offered for an initial term of two years, with the possibility of prolongation for up to two additional years, and an option for a permanent position. The positions are intended to suit those with typically up to four years postgraduate research experience who would, once established, be in a strong position to enter a research management career path either in academia or industry. The positions include generous funding packages covering personal salary and consumables, as well as access to the core facilities of neighboring research institutions and biotechnology companies. There is flexibility over starting dates, but successful applicants are anticipated to take up post by July 1, 2013.


Application & Selection Process

Applications are to be made online at http://www.bio.mx.

Only applications received before Sunday April 7, 2013 will be considered. As part of the online application procedure candidates will be required to upload a CV, provide supporting statements and project proposals.

After a first selection round, candidates will be invited to a five-day assessment center workshop in Heidelberg. The invitation includes full coverage of travel expenses, accommodation, sightseeing, and food for the entire workshop which will take place from April 29 to May 3, 2013. With guidance of experienced mentors, candidates will jointly work on their project proposals and present them in front of a jury on the final day. Successful candidates will be offered a position at the BioMed X Innovation Center.

Germany: Postdoctoral Researcher position at BioMed X Innovation Center

About BioMed X

The BioMed X Innovation Center constitutes a novel way of collaboration at the interface between academia and industry. Young life science talents from all over the world will be working jointly on pre-clinical research topics in the fields of biomedicine, molecular biology, cell biology and chemoinformatics. Interdisciplinary project teams are collaborating in an open-innovation lab facility on the campus of the University of Heidelberg, with guidance of experienced mentors while expanding their scientific network and receiving an intensive entrepreneurship and leadership training.


What we are looking for

Applications are invited from outstanding early-career scientists working or interested in one of the following fields of research:


1. Cancer & Inflammation:

The immunosuppressive microenvironment of tumors applying methods for the identification of new targets for immunotherapy of cancer
2. Metabolism & Signaling in Cancer:

Cross-talk between signaling and metabolism in cancer and identification of new metabolic targets for cancer therapy
3. Selective Kinase Inhibitors:

Computational and/or knowledge-based models for prediction of kinase specificity and development of software for the identification and design of novel selective kinase inhibitors or inhibitors of other large target classes


What we offer

Eight postdoctoral researcher positions are offered for an initial term of two years, with the possibility of prolongation for up to two additional years, and an option for a permanent position. The positions are intended to suit those with typically up to four years postdoctoral experience who would, once established, be in a strong position to enter a research group leader career path either in academia or industry. The positions include generous funding packages covering personal salary and consumables, as well as access to the core facilities of neighboring research institutions and biotechnology companies. There is flexibility over starting dates, but successful applicants are anticipated to take up post by July 1, 2013.


Application & Selection Process

Applications are to be made online at http://www.bio.mx.

Only applications received before Sunday April 7, 2013 will be considered. As part of the online application procedure candidates will be required to upload a CV, provide supporting statements and project proposals.

After a first selection round, candidates will be invited to a five-day assessment center workshop in Heidelberg. The invitation includes full coverage of travel expenses, accommodation, sightseeing, and food for the entire workshop which will take place from April 29 to May 3, 2013. With guidance of experienced mentors, candidates will jointly work on their project proposals and present them in front of a jury on the final day. Successful candidates will be offered a position at the BioMed X Innovation Center.