This position provides an opportunity to explore the gene-to-structure process in an industrial setting. You'll be exposed to a variety of aspects within the drug discovery cascade, and will interact with scientists in a cross-disciplinary environment. You'll also be expected to deliver your novel research results within AstraZeneca, and externally via scientific conferences and peer-reviewed publications.
Your major responsibilities
* Build an understanding of antibiotic selectivity for the bacterial ribosome through the design and analysis of the functional activity of chimeric ribosomes
* Assess the antibacterial sensitivity of recombinant bacterial strains containing chimeric ribosomes against a panel of known ribosomal inhibitors
* Understand the structural basis of ribosomal inhibitor selectivity by performing crystallography on chimeric ribosomes in complex with antibiotics
* Work collaboratively with scientists across various disciplines to achieve project objectives
* Externally present results at scientific conferences, and publish scientific papers in high quality peer-reviewed journals
Minimum experience
A PhD in one or more of the following areas:
* Protein/RNA biochemistry
* Biophysics, crystallography, ribosome biology, molecular microbiology
Preferred experience/requirements
* Molecular biology, expression and purification skills to independently produce high-quality RNA-protein complexes
* Experience with multiple biochemical and biophysical techniques to assess the quality, stability and function of RNA-protein complexes
* Experience in performing antibacterial sensitivity assays
* Experience in designing complex reagents for biophysical and crystallographic studies
* Crystallographic experience is highly desirable
* Strong written and oral communication skills
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