USA: Postdoctoral position to study hematopoietic stem cells

A postdoctoral position is available at UCSF Benioff Children’s Hospital to study the optimal conditions for gene-correction of hematopoietic stem cells in a mouse model of Artemis-deficient severe combined immunodeficiency (SCID-A). This project will: 1) Optimize lentiviral-mediated gene transduction in murine hematopoietic stem cells (HSC) and 2) Establish conditions to maximize engraftment of Artemis-corrected congenic HSC by opening bone marrow niches without high dose chemotherapy. The postdoc would be responsible for designing and implementing experiments for optimizing gene transduction conditions and opening marrow niches using chemotherapy and non-chemotherapy agents in a mouse model of Artemis SCID, analyzing and presenting results and preparing manuscripts for publication.

Requirements: Working with mouse models, flow cytometry and sorting, familiarity with assays of immune function is essential. Experience in gene transduction using lentiviral vectors is desirable. Applicants must have a PhD, but no more than 5 years of postdoctoral training. This position is available starting immediately and salary commensurate to experience. UCSF is an Equal Opportunity/Affirmative Action Employer. The University undertakes affirmative action to assure equal employment opportunity for underutilized minorities and women, for persons with disabilities, and for covered veterans. All qualified applicants are encouraged to apply, including minorities and women.

To apply: Interested applicants should submit a CV, a brief description of research accomplishments, interests and career goals, and contact information (email address and phone number) of three references tomcowan@peds.ucsf.edu.

Dean’s Postdoctoral Fellowship at Harvard Medical School

The Dean’s Postdoctoral Fellowship at Harvard Medical School is a 2-year postdoctoral research fellowship sponsored by the Office for Diversity Inclusion and Community Partnership and the Office for Postdoctoral Fellows.

The Dean’s Postdoctoral Fellowship is accepting applications from postdoctoral scientists, particularly from underrepresented and disadvantaged backgrounds, in the fields of basic or social sciences. The Dean’s Postdoctoral Fellowship will prepare postdoctoral researchers for cutting-edge research careers. Postdoctoral fellows will benefit from the highly innovative and creative research environment at Harvard Medical School that emphasizes scientific rigor, collaboration and the pursuit of excellence in science. This fellowship will position the right candidate to make major contributions as scientific and societal leaders.

Applications are being considered on a rolling basis for positions in the following departments on the Quadrangle:

• Biological Chemistry and Molecular Pharmacology
• Cell Biology
• Genetics
• Global Health and Social Medicine
• Health Care Policy
• Microbiology and Immunobiology
• Neurobiology
• Stem Cell and Regenerative Biology
• Systems Biology
• Wyss Institute for Biologically Inspired Engineering

ELIGIBILITY - Candidates must have:

• completed MD, PhD, ScD, or equivalent in the basic or social sciences by the start date of this research fellowship
• less than five years of relevant postdoctoral research experience
• United States citizenship or permanent residency
• demonstrated motivation for career advancement in research and scholarly excellence

Ordinarily candidates will have at least one first authored publication and some conference presentations. Graduates of Harvard Medical School PhD and MD programs should not apply to work with faculty of the department that granted their doctorate.

ONLINE APPLICATION - Applications must be submitted online and are currently accepted on a rolling basis. Qualified applicants will be selected by the laboratory or program and a committee with representatives from various departments.

To apply: To apply or learn more about this opportunity, please visit:http://www.hms.harvard.edu/dcp/deanspdfellowship.

For more information, please contact: Brian L. Anderson, Program Manager, Harvard Medical School, Office for Diversity Inclusion and Community Partnership, 164 Longwood Avenue, 2nd Floor, Boston, MA 02115-5818; Tel: 617-432-1083; Fax: 617-432-3834; E-mail: dcp_deanspostdoc@hms.harvard.edu.

Postdoctoral fellow position molecular and stem cell biology 2013, USA

A postdoctoral fellow/research associate position is available in the laboratory of Michael Oertel in the Dept. of Pathology (Div. of Experimental Pathology), University of Pittsburgh. The laboratory focuses on stem cells, regeneration, and cell transplantation in the liver with the goal to develop novel strategies for therapeutic tissue replacement.

We are looking for a highly talented and motivated person to carry out research to characterize candidate donor stem/progenitor cells and investigate their repopulation potential in rodent cell transplantation models, as well as the mechanism(s) regulating liver tissue replacement.

Applicants must possess a Ph.D., should have a strong background in molecular and stem cell biology, as well as extensive knowledge in liver related research. We are looking for a successful candidate with good analytical and interpersonal skills, who should be capable to work independently. Experience in molecular and cell biology techniques, including RNA, DNA and protein isolation, PCR, and Western Blot, is required. Expertise in laser capture microscopy is preferred. Experience with cell culture, cell isolation and immunohistochemistry, and proficiency in rat models, including surgical techniques, is desired.

To apply please email a cover letter, CV, summary of previous research experiences, and the contact information of at least 2 references to Michael Oertel, Ph.D., at mio19@pitt.edu.

Application Deadline: Open Until Filled

Postdoctoral position in cardiovascular diseases 2013, Spain

Applicants must be experienced researchers with a doctoral degree related to medical/biological sciences and interest in cardiovascular diseases. Applicants must possess a strong publication record, with experience in molecular biology, cell biology and signaling.  Experience with animal models of regeneration and hematopoietic/cardiac stem cells is preferable.

We offer a 2 year contract with competitive salary according to the experience of the selected candidate. The CNIC has an advanced policy on matters of welfare benefits, with the most modern flexible remuneration systems.

To apply
Qualified applicants should submit an application by e-mail, including a letter outlining research interests, a CV, and the contact information of three referees, to Eduardo Bieger (ebieger@cnic.es)

http://www.cnic.es/en/inflamacion/metaloproteinasas/index.php

Post-doctoral Fellowship in Brain tumor stem cells 2013 USA

Post-doctoral fellowship position available at the University of Alabama at Birmingham for candidate interested in brain tumor research related to the characterization of cancer stem cells/brain tumor initiating cells. The cancer stem cell hypothesis posits that a hierarchy exists in some cancers with self-renewing cancer stem cells generating progeny constituting the remainder of the tumor. The presence of highly tumorigenic cancer stem cells has been demonstrated for brain tumors including glioblastoma, the most lethal and prevalent primary malignant brain tumor in adults. Glioblastoma stem cells have been demonstrated to be radio- and chemoresistant as well as highly angiogenic, suggesting the importance of targeting these cells for patient therapies.
We seek to better understand the molecular and biological mechanisms through which brain tumor stem cells drive tumor maintenance in order to identify novel targets for cancer therapy. Applicants should have a Ph.D in Cancer Biology, Molecular Biology, Pharmacology, Neuroscience, or a closely related field.

Candidates must have prior experience with cell culture and molecular biology techniques such as purification of nucleic acids, quantitative real-time PCR, and immunoblotting. Prior experience with production of lentivirus, xenograft models, measurement of DNA repair, immunofluorescence/confocal imaging and/or isolation of primary cells desired. Applicants must be willing to work with human cells and mouse models. Must have strong organizational skills and be detail oriented. Ability to work well independently and apply scientific principles to the solution of novel problems needed. Must work well as part of a team and recognize the benefits of collaboration, taking initiative, and offering constructive criticism.

Chosen candidates will be expected to work with undergraduates and technicians in the laboratory to accomplish experimental goals. In addition to data production, candidates will be expected to communicate findings via the preparation of manuscripts and grants. If interested, e-mail your cover letter, CV, and contact information for three references to Dr. Anita Hjelmeland at hjelmea@uab.edu.

Biophotonics Postdoctoral research position 2013 USA

A postdoctoral research position in the area of nonlinear optical microscopy and microfluidic systems is available at the NSF Center for Biophotonics Science and Technology at UC Davis. The project will involve the development of novel nonlinear optical techniques and integration with microfluidic systems for analyzing single cells.
Qualified applicants should have demonstrated experience in one or more of the following areas: biophotonics (nonlinear optics), microfluidics, and stem cells. Applicants should have a recent Ph.D. in engineering, physics, optics, chemistry or a related field. Experience and knowledge in optics, optical instrument development, microfluidic design and fabrication, stem cells, and computer programming (e.g. LabView) are highly desired.

To apply

To apply for the position, please e-mail a letter of interest, CV, and the names of three references to Prof. James Chan (james.chan@cbst.ucdavis.edu). Please include "Postdoc Position in Biophotonics/Microfluidics" in the Subject Heading of your email.

For More information

Postdoctoral Research Scientist position Regenerative Stem Cell Research 2013 - UK

We are seeking to appoint a highly motivated Post-doctoral Research Scientist working between Oxford NHS Blood and Transplant and the University of Oxford and who will work as part of a team. The successful candidate will conduct a research project aimed at understanding the microenvironmental influences on blood vessel formation, particularly as they relate to mesenchymal stem/stromal cells. The ultimate aim of this project will be to develop new methods for robustly defining and expanding mesenchymal and endothelial stem/progenitor cells so that they can be used therapeutically.

The specific project involves the isolation using magnetic beads or flow cytometry and culture of mesenchymal and endothelial stem/progenitor cell subsets, assessment of homing potential using novel chemotaxis assays based on timelapse microscopy, expansion studies, genetic manipulation and gene, proteomic or cell signalling analyses.

Requirements: 

The post would be suitable for a recent postdoctoral scientist with relevant molecular and cell biology experience in the appropriate area of research. Expertise in cell isolation, culture, identification using flow cytometry and immunohstochemistry, manipulation, expansion gene or proteome analyses and tracking of cells in in vitro model systems would be an advantage. The post is available immediately until September 30th 2015. Interactions with collaborators at the Weatherall Institute of Molecular Medicine and other departments within the University of Oxford will be required.

For More Information

China: Postdoc positions to study noncoding RNA functions 2013

Postdoc positions are available immediately to study noncoding RNA functions in development of neural stem cells and in formation of human and mouse brains (Bian et al., 2013 Cell Reports; Otaegi et al., 2011, J. of Neurosc.; Kawase-Koga et al., J. of Cell Science). Candidates with a strong background in RNA biochemistry, mouse genetics, stem cell culture, bioinformatics, and/or molecular biology are strongly encouraged to apply. Competitive salary and benefits.

Candidates may take a short training at Cornell University Weill Medical College at New York City, and will be working full time at Shanghai Jiao Tong University in Shanghai, China. Successful candidates have the opportunity to be promoted to positions equivalent to Assistant or Associate Professor in a short period time.

Please send cover letter, research interests, CV, publications and three names who can provide recommendation letters in Word or PDF files by email to Dr. Sun at taosun11@sjtu.edu.cn or tas2009@med.cornell.edu.

Postdoctoral position in Tumor stem cell biology - 2013 Israel

M.Sc. and Ph.D. students as well as Post-Doctoral fellows are invited to join the laboratory of Cytokine Biology, in the Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences

Major scientific projects of the laboratory include:

1) The role of inflammation in the malignant process (carcinogenesis, tumor invasion and metastasis, tumor angiogenesis and interactions of the tumor with the host’s immune system).

2) Interleukin-1 (IL-1) receptor and Toll-like receptor (TLR) signaling in sterile inflammation and angiogenesis in the malignant process.

3) Mechanisms and signaling pathways of novel intracellular non-secretable isoforms of the cytokine IL-1a.

4) Intervention in IL-1 expression in anti-tumor therapeutic approaches.

Techniques used in the laboratory include tissue culture and in vitro
work, molecular biology techniques and in vivo work.  These are applied to cutting-edge issues in cytokine and tumor immunobiology, stem cell biology and angiogenesis. Excellent teamwork and atmosphere

          To apply

more information can be found here:
 https://sites.google.com/site/raptehome/home

Please apply to Prof. Ronnie Apte, +972-8-647-7270,
Goldman Medical School Building, Rm. 131 (rapte@bgu.ac.il)

Cell biology postdoctoral position - 2013 United States

A postdoctoral position is available in our lab at the Stem Cell Institute, University of Minnesota. We have recently discovered that a fusion protein between the transactivation domain of the MyoD protein and the pluripotency factor Oct4 can drastically increase the efficiency of making iPS cells (Stem Cells, 2011, 29:1349; PLoS ONE, 2012, 7: e34149; PLoS ONE, 2012, 7: e39022). Developing this study, we are now studying the roles of long noncoding RNAs in pluripotency of ES cells and iPS cells, as well as in oncogenesis using RNA-ChIP and RNA-seq. The recently developed TAL effector technology will also be incorporated. Strong interest or experience in bioinformatics (microarray, RNA-seq and various gene analysis programs) is preferred, in addition to the standard cell culture and molecular biology techniques. Understanding of stem cell biology is also preferred.
To apply

 Please email CV and names of three references to below.

    

    Nobuaki Kikyo M.D., Ph.D.

    Associate Professor of Genetics, Cell Biology and Development

    University of Minnesota

    Stem Cell Institute

    Minneapolis MN 55455

    Phone 612-624-0498

    FAX 612-624-2436

    Email kikyo001@umn.edu

Postdoc position in stem cell biology - 2013 United States

The Center for Pediatric Nanomedicine, a research center sponsored by Children’s Healthcare of Atlanta, Georgia Tech, and Emory University, is seeking a postdoctoral fellow to work on human pluripotent stem cells (website). The research is focused on differentiation of cardiomyocytes from pluripotent stem cells and will be conducted in collaboration with investigators in Children's Healthcare of Atlanta, Georgia Tech, and Emory University. The candidates should have a recent Ph.D. preferably in Cell Biology or related disciplines with strong cellular and molecular biology expertise including cell culture, immunocytochemistry, flow cytometry analysis, qRT-PCR, and generation of expressing vectors. The candidate will conduct independent research and collaborate with members in the group and is expected to actively participate in experimental planning, data analysis, and manuscript writing.

To apply please send curriculum vitae, the names of 3 references, and a cover letter describing your research experience and interests to Dr. Chunhui Xu at chunhui.xu@emory.edu.

For More Information

Postdoctoral positionto study transcriptional and epigenetic regulation - USA

A postdoctoral position is available to study transcriptional and epigenetic regulation of vertebrate neural development in the laboratory of Kristen L. Kroll at Washington University School of Medicine. We are defining how cells of the early embryo and embryonic stem cells control neural fate acquisition, neural stem and precursor cell maintenance, and neuronal differentiation. We are using genome-wide approaches to define the transcriptional regulatory networks that control neural development and are characterizing how epigenetic regulation modulates these neural gene regulatory networks. We are also assessing how dysregulation of epigenetic activities contributes to malignancy in medulloblastoma and glioblastoma. Biochemical and molecular characterization of essential regulatory molecules is complemented by work in mouse animal models and in mouse and/or human embryonic stem cell, neural stem cell, and other cell-based models. For additional information see: http://devbio.wustl.edu/krolllab/index.html or http://dbbs.wustl.edu/faculty/Pages/faculty_bio.aspx?SID=4039

Setting/Salary/Benefits:
Our laboratory is in an academic setting in the Department of Developmental Biology at Washington University School of Medicine (St. Louis), an internationally recognized research institution with a dynamic research environment and extensive infrastructural and core facility support. Postdoctoral appointees at Washington University receive a starting salary based on the NIH NRSA guidelines and a generous benefit package. Complete information on the benefit package is located on the WUSM Human Resources Benefits Website (http://medschoolhr.wustl.edu). The St. Louis area combines the attractions of a major city with family-friendly and affordable lifestyle opportunities (http://www.stlouis.com/).

Qualifications:
Candidates should hold a recent PhD with less than 2 years of prior post-doctoral experience. Preference will be given to applicants with a strong interest in and research training relevant to the areas of vertebrate neural development, stem cell biology, and transcriptional or epigenetic regulation. US citizens are preferred. Interested candidates should send a CV/names of references by email to kkroll@wustl.edu or by regular mail to Kristen L. Kroll, Washington University School of Medicine, Campus Box 8103, 660 S. Euclid Ave, St. Louis, MO 63110.

Application Deadline: Open Until Filled

Postdoctoral Fellow in Bioinformatics and Stem Cell Biology - USA

We are seeking a highly motivated postdoctoral fellow to study stem cell biology using Systems Biology approaches in the Department of Neurosurgery, and Center for Stem Cell and Regenerative Medicine at the University of Texas Medical School at Houston.

Our laboratory combines stem cell biology and systems-based approaches involving functional genomics and next-generation sequencing technologies including RNA-Seq and ChIP-Seq and functional tests to unravel gene transcription and regulatory mechanisms governing neural differentiation. We are currently pursuing basic and translational research in neural repair and neuroprotection in regenerative medicine. The other area of our research interest lies in the studies of the regulatory networks of hematopoietic precursor cell self-renewal and differentiation.

Requirements:
Qualified candidates should:
• Have strong background and skills in bioinformatics, statistics and next-generation sequencing data analysis; biological experimental background and knowledge are preferred
• Demonstrated proficiency as evidenced by relevant publications in peer-reviewed journals and is interested in acquiring new skills.
The candidate will have the opportunity to pursue highly collaborative projects with significant translational impact, alongside with stem cell researchers and clinicians.



About us:
Our lab is located in the beautiful new facility of the Brown Foundation Institute of Molecular Medicine in the Texas Medical Center. Texas Medical Center is one of largest medical complex in the world and provides access to the more than 40 member institutions, including two medical schools, four schools of nursing and 13 renowned hospitals. Many scientific and educational opportunities are available in the metropolitan area of Houston as well as cultural, entertainment and sports activities.

How to Apply:
Please email your application including a CV, a summary of previous research, a statement of interest and career objectives, and contact information of 3-5 referees to:
Dr. Jiaqian Wu, Ph.D.
Department of Neurosurgery
Center for Stem Cell and Regenerative Medicine
The University of Texas Medical School at Houston
Email: Jiaqian.Wu@uth.tmc.edu

Postdoctoral Position at the Institute for Clinical Neurobiology - 2013 Germany

Open Postdoctoral Position at the Institute for Clinical Neurobiology,
University Hospital, Julius-Maximilians-Universität Würzburg

The Institute for Clinical Neurobiology seeks a postdoctoral fellow for expanding our research on iPS cell technologies to generate motoneurons and other types of neurons for analysis of molecular pathomechanisms of neuro- degeneration. The institute has long-standing expertise in characterization of disease mechanisms in motoneuron disease, using mouse and cell culture models. The aim of our work is to validate new mouse- and patient-derived iPS cells in state-of-art cell culture models to study defects in neurotrophin signaling pathways and signaling pathways for axon stabilization and maintenance. For further information, see recent publications from our lab (Selvaraj et al., JCB 2012, doi: 10.1083/jcb.201203109, Pühringer et al., Nature Neuroscience 2013, doi:10.1038/nn.3333).

We are looking for a highly motivated scientist with good background in stem cell biology. The candidate will use molecular biology methods including viral tools and advanced cell culture techniques, including compartmentalized cultures for studying alterations in proteome and transcriptome in axonal compartments. Experience with mouse embryonic cell culture techniques is of advantage.

The project profits from a strong cooperation and knowledge transfer between partner groups. The applicant will find a project which is well embedded in the research focus of our Institute. He/she will have access to a modern and well- equipped research facility and will work with already available mouse models.

Applications from severely handicapped persons with basically similar qualifications will be given priority. Salary will be according to TV-L.

Interested candidates should email a CV, a brief statement of research interest, representative publications and name two references to:

Prof. Michael Sendtner, Institute for Clinical Neurobiology University Hospital of Würzburg - E4 - Versbacher Str. 5 · 97078 Würzburg

Email of our secretary: Grimm_J@klinik.uni-wuerzburg.de http://neurobiologie.uk-wuerzburg.de/

USA: Postdoctoral Research position - epigenetics/ stem cell research at University of Illinois

The Department of Medicine at the University of Illinois at Chicago is seeking to fill a Postdoctoral Research position in the laboratory of Dr. Joseph DeSimone. Our research focus is on the epigenetic regulation of gene expression during hematopoietic stem cell differentiation. Our aim is to increase the understanding of hemoglobin switching with the goal of developing innovative hemoglobinopathies therapies.
We seek highly qualified, dedicated and highly motivated individuals with a commitment to research excellence and with experience in ChIP and bisulfate sequence analysis and hematopoietic progenitor cell purification from primary bone marrow cells. Research experience in animal models would be an advantage. The candidate should have a pro-active attitude and able to contribute to papers.
Interested applicants should send a cover letter describing their research interests and motivation for the position and a detailed CV (with research experience, scientific and technical skills, publication and conference presentation list, contact information of at least 3 references) to Dr. Joseph DeSimone, University of Illinois @ Chicago, email- jdesimon@uic.edu.

Eligibility criteria:
- PhD/MD or PhD will have been awarded by start date
- At least one publication in an inter-disciplinary or specialized peer-reviewed journal
UIC is an AA/EOE. Women and Minorities are encouraged to apply.