A postdoctoral position is available at UCSF Benioff Children’s Hospital to study the optimal conditions for gene-correction of hematopoietic stem cells in a mouse model of Artemis-deficient severe combined immunodeficiency (SCID-A). This project will: 1) Optimize lentiviral-mediated gene transduction in murine hematopoietic stem cells (HSC) and 2) Establish conditions to maximize engraftment of Artemis-corrected congenic HSC by opening bone marrow niches without high dose chemotherapy. The postdoc would be responsible for designing and implementing experiments for optimizing gene transduction conditions and opening marrow niches using chemotherapy and non-chemotherapy agents in a mouse model of Artemis SCID, analyzing and presenting results and preparing manuscripts for publication.
Requirements: Working with mouse models, flow cytometry and sorting, familiarity with assays of immune function is essential. Experience in gene transduction using lentiviral vectors is desirable. Applicants must have a PhD, but no more than 5 years of postdoctoral training. This position is available starting immediately and salary commensurate to experience. UCSF is an Equal Opportunity/Affirmative Action Employer. The University undertakes affirmative action to assure equal employment opportunity for underutilized minorities and women, for persons with disabilities, and for covered veterans. All qualified applicants are encouraged to apply, including minorities and women.
To apply: Interested applicants should submit a CV, a brief description of research accomplishments, interests and career goals, and contact information (email address and phone number) of three references tomcowan@peds.ucsf.edu.