A PhD position and a postdoctoral position are available in project 1 (Feil) of the newly established DFG Research Unit FOR 2060. Project start is summer 2013. The Research Unit investigates the function of the intracellular signalling molecule, cyclic guanosine monophosphate (cGMP) in mammals, specifically in tissue degeneration and regeneration. Project 1 studies the role of global and local cGMP signals in growth control. We use fluorescence-based cGMP sensor proteins to visualize changes of the signalling molecule in living cells in real time. This will allow us to monitor the spatiotemporal dynamics of cGMP signalling under various conditions and to correlate the respective cGMP signals with associated alterations in the growth of cardiovascular and neuronal cells. The projects involve analyses at the molecular, cellular and whole organism level. Candidates should be interested to work at the interface of biochemistry and biomedicine, with a focus on cell signalling under native conditions. Experience in the fields of signal transduction, transgenic mouse technology, and/or live cell imaging would be an advantage.
For recent project-relevant publications of our group, see:
Original Article: Thunemann, Wen et al. (2013). Transgenic mice for cGMP imaging. Circ Res, in press.
Methods Article: Thunemann et al. (2013). Visualization of cGMP with cGi biosensors. Methods Mol Biol 1020, 89-120.
Review Article: Kemp-Harper & Feil (2008). Meeting report: cGMP matters. Sci Signal 1, pe12.
For further information, please visit www.cyclic-gmp.de or www.ifib.uni-tuebingen.de/forschung/feil.html.
Please send your application (including names/emails of 2 referees) to Prof. Dr. Robert Feil, University of Tübingen, Interfakultäres Insitut für Biochemie (robert.feil@uni-tuebingen.de).
Deadline for applications: 16 August 2013