2 Postdoc positions:
The microenvironmental control of tumor progression and metastasis
The microenvironmental control of tumor progression and metastasis
The positions are available immediately.
Your profile:
We are looking for enthusiastic and highly motivated applicants holding, or about to obtain, a PhD degree. The applicants should possess a strong research background in molecular and cell biology, experience in cancer research will be an advantage. Preference will be given to applicants with previous experience in one or more of the following areas: protein biochemistry, analysis of signalling pathways, proteomic analysis including analysis of posttranslational modifications, hypoxic signalling, functional genomics or other high-throughput screening methods, epigenetics or in vivo tumor metastasis models.
Topic:
Our group has a long-standing interest in the role of microenvironmental factors, particularly hypoxia, hypoxia inducible factors (HIFs) and oxygen sensors of the PHD family, in the regulation of tumor progression and key hallmarks of cancer including angiogenesis, invasion, metastasis, metabolism and differentiation. Our main research interest is to understand the role of microenvironmental sensors and their downstream targets in tumor progression and metastasis.
The proposed projects will aim to dissect the intersection of oxygen sensing pathways with other cellular signalling pathways, including growth factor/RTK and Notch signalling, which are involved in cancer cell proliferation, invasion, metastasis and self-renewal.
What we offer:
Our international team offers an open, supportive, dynamic and motivating academic environment with excellent training opportunities. We have won a number of external research grants and are involved in several national and international collaborative projects. We use a wide spectrum of methods: cloning, cell culture, biochemistry, qRT-PCR, FACS, ELISA, cell-based assays (proliferation, apoptosis, migration, 3D invasion, stem cell isolation and cultivation etc.), shRNA screens, proteomics, transactivation assays, virally-based gene delivery and RNAi silencing, immunohistochemistry, in situ hybridization, light, epifluorescence and confocal microscopy, image analysis, animal models and in vivo tumor models.
Application:
Please send your applications, including a CV, certificates and references to Dr. Boyan Garvalov
Email: Boyan.Garvalov {at} patho.med.uni-giessen.de;
Please cite reference “Jobvector2013-06”.
Website: http://www.ukgm.de/ugm_2/deu/ugi_npa/5424.html
Selected references:
Filatova et al, Biochim Biophys Acta 2013, 1830(2):2496-508
Sawamiphak et al, Nature 2010; 465(7297):487-91
Henze et al, Cancer Research 2010;70(1):357-66
Seidel et al, Brain 2010;133(4):983-95
Acker et al, Cancer Cell 2005; 8(2):131-41
Compernolle et al, Nature Medicine 2002; 8(7):702-10