Postdoctoral Fellow - RNA-seq - Single Cell Genomics
Wellcome Trust Sanger Institute
Cambridge, United Kingdom
Ref: 81442
Salary range from £29,388 to £36,840 with a discretionary range to £39,721 per annum plus excellent benefits
The Wellcome Trust Sanger Institute is currently seeking highly talented postdoctoral fellows with strong laboratory and/or analytical skills to join the new Sanger-EBI Single Cell Genomics Centre.
Single cell genomics - DNA-seq, epigenome-seq and RNA-seq - is the next frontier in molecular biology, providing a whole-genome view of genetic variability at the single cell level. These new approaches present new computational and experimental challenges and opportunities.
The ability to accurately measure DNA-, methyl DNA- and RNA-sequence from single cells will revolutionise our understanding of somatic genomic variation, cell type differences, developmental processes, the degree of stochasticity of transcript levels amongst cells of the same type, DNA-mutation rates and mechanisms, genetic mosaicism and disease/phenotype aetiology.
In order to exploit the new developing technologies, five faculty members across the Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute, both on the Wellcome Trust Genome Campus in Hinxton, Cambridge, UK, have launched a joint programme in single cell genomics.
The positions will be allocated to 4 areas:
- DNA-seq;
- Epigenome-seq;
- RNA-seq;
- Computational approaches.
Essential Skills
- A PhD in Genomics, Genetics, (Computational) Biology (or similar), and a passion for problem solving;
- (DNA-seq, epigenome-seq and RNA-seq) proven cell culture and molecular biology skills are an essential requirement, including: DNA- and RNA-extraction methods, amplification protocols, molecular cloning, vector construction, sequencing protocols;
- Excellent written and spoken English are essential;
- The ability to effectively communicate with collaborators and occasionally present oral communication to large groups;
- Proven independent working style, technical problem solving, data analysis and generation of novel ideas.
- Extensive programming experience and computational analysis of next generation sequence data;
- Good experience with cell culture, (single-cell) DNA- and RNA-seq protocols;
- Good mix of wet-lab and bioinformatics/computational skills;
- Experience in supervising and training other laboratory personnel in specialized techniques and presenting results at scientific conferences [posters and talks].
As a world leader in human genomics, genome informatics, and whole genome DNA sequencing, the Wellcome Trust Sanger Institute (WTSI) is now focusing large-scale genotyping, DNA sequencing, and mathematical analysis on illuminating the biology of different cell types.
Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. The post is a two year fixed-term contract.
Successful applicant(s) who have submitted their PhD thesis and are awaiting their PhD award to be confirmed will be placed on a transitional pay point, £ 27,000 per annum. On confirmation applicants will be moved on to the pay scale above.
Closing date for applications is 30th April 2013
Benefits
The Institute has excellent purpose built facilities on the Genome Campus, Hinxton on the outskirts of Cambridge. We offer a comprehensive range of benefits including a final salary pension scheme and excellent on-site facilities. Further details can be found on our website https://jobs.sanger.ac.uk.
To submit your CV and apply for this job please go to https://jobs.sanger.ac.uk, to register and apply on line.]