• How gene expression is controlled;
• How this system regulates biologically important behaviours;
• And how a breakdown in this system leads to human diseases.
As part of our recent move to the LRI,
we will increasingly focus towards understanding gene regulation and
evolution in the context of human diseases and cancer.
Recent research successes include:
investigations of evolutionary processes in bacterial genomes
(Martincorena et al, Nature 2012); mechanisms of epigenetic regulation
in sex determination (Conrad et al, Science 2012); qualitative models of
nucleosome-positioning and transcriptional regulation (Zaugg &
Luscombe, Genome Res 2012); and a new mechanism to supress aberrant exon
formation (Zarnack et al, Cell 2013).
Proposed projects
In this round of applications, we are
particularly seeking researchers interested in working on our
collaboration with Professor and Jernej Ule (UCL) to investigate
protein-RNA interactions on a transcriptome-wide scale, how RNA
processing is regulated, and the impact these have on neural functions.
The postdoc will be expected to
perform an entirely computational project using publically available
datasets, and in parallel, lead a wet/dry collaboratory project with
Professor Ule’s laboratory.
Requirements:
We welcome applications from candidates
with diverse educational backgrounds. The ideal candidate will have
recently completed or be completing a PhD degree in Biology (molecular
biology, genetics, genomics), Computational Biology (bioinformatics,
systems biology) or Statistics. Applicants must have a proven
publication record.
A computing background is not strictly
necessary, but you must be keen to work in a dry setting. For applicants
with computing experience, fluency in Linux, and excellent knowledge in
a programming language is expected (Perl, Python, C/C++,
R/BioConductor, MatLab etc).
Prior experience with handling
genome-scale data is advantageous: examples include genome sequence and
high-throughput-sequencing data for a range of research applications
such as gene expression, protein-DNA/RNA binding, and chromatin
conformation measurements.
Postdocs are expected to develop and
lead projects, and help supervise junior members of the laboratory. The
ability to work in a team is essential.
About us:
The London Reseach Institute has an
international reputation for cutting edge research into basic biology
and it is committed to training the next generation of research
scientists. The four-year LRI Postdoctoral Programme is part of this
commitment, and nearly half of Postdoctoral Fellows leave to set up
their own research groups. Postdocs also benefit from living and working
in one of the world’s greatest scientific, cultural and cosmopolitan
capital cities.
The LRI will become part of the Francis
Crick Institute in 2015, which will be an entirely new institute with a
distinctive vision of how biomedical research in conducted. It will be
one of the most significant projects inUKbiomedical science for a
generation.
Closing Date: 19th June 2013