Postdoctoral Position to study Programmed DNA Elimination 2013 USA

Postdoctoral position available to study PROGRAMMED DNA ELIMINATION in NEMATODES (Chromatin Diminution). In the nematode Ascaris, 15% of the genome is eliminated in the somatic lineages during the 3rd through 5th cleavage (4 to 16 cell stage), while the germline genome remains intact. ~700 germline and early development expressed genes are eliminated. Chromosomes break, regions are lost, and new and increased numbers of chromosomes are formed. Areas under investigation include analysis of 1) how genome regions are marked for retention or elimination, 2) how break regions are identified and the mechanism of chromosome breaks, 3) how eliminated chromosome regions are selectively lost from holocentric chromosomes, and 4) the contributions of histone modifications (including CenpA) and non-coding RNAs to DNA elimination. For a recent paper, see Developmental Cell 2012. 23:1072–1080.
For additional information on the laboratory's research and recent publications, see http://140.226.65.22/Davis_lab/index.html
The University of Colorado School of Medicine, is located in a brand-new, state-of-the-art facility on the Anschutz Medical Campus. The Department of Biochemistry and Molecular Genetics provides an exciting, interactive and collegial scientific environment.

Denver, CO is an affordable multicultural, metropolitan city. The nearby Rocky Mountains offer a spectacular scenic backdrop and an array of outdoor recreational opportunities within a 15-minute to two-hour drive from Denver. The climate in Denver is relatively mild and dry, and Denver boasts over 300 days of sunshine per year! Winters are mild, with average daytime highs of 45 degrees; summers are warm and dry, with average daytime highs of 85 degrees.

Applicant must have PhD degree in Biological Sciences, Chemistry, Biochemistry, Molecular Biology, Genetics, Cell Biology, or a related field within the last three years. Applicant must have excellent communication skills using the English language. Applicants should have demonstrated scholarship through publication in internationally recognized English language journals.

Candidate is expected to be curious, highly motivated and able to design and carry out creative, independent research, write fellowship applications (if applicable), and publish.

Applicants should have significant experience in at least one or more of the following:
1. Epigenetics, chromatin, DNA damage/repair, or genomics
2. Mitosis, centromeres, or chromosome segregation
3. ChiP and ChiP-seq
4. Genomics and Bioinformatics
5. Non-coding RNAs and chromatin
6. Immunocytochemistry of nuclei and chromosomes including DNA and/or RNA FISH
7. Laser ablation and microinjection
8. C. elegans

Applications will be reviewed until suitable candidates are identified.
Applicants should apply by e-mail to richard.davis@ucdenver.edu
Applications should contain:
1. A letter of application including a short description of previous research experience, goals, and interests in our research
2. Curriculum Vitae
3. Contact information for three references
4. Start date availability

Full contact information:
Richard E. Davis, Ph.D.
Dept. of Biochemistry and Molecular Genetics
University of Colorado School of Medicine
RC-1 South, RM 10121, MS 8101
12801 East 17th Ave
Aurora, CO 80045
Tel: 303-724-3226
Fax: 303-724-3215

 Application Deadline:     Open Until Filled