Postdoctoral Research Fellow in Computational Biology at SciLifeLab Sweden

KTH is the largest technical university in Sweden. Education and research cover a broad spectrum within natural sciences and engineering, as well as architecture, industrial engineering and management, urban planning, work science and environmental engineering. KTH has 15000 under-graduate students, 1600 students at doctoral level (third) level and 4300 employees.

The School of Biotechnology at the Royal Institute of Technology offers a curriculum that reflects the multidisciplinary nature of Biotechnology, integrating theoretical and applied science in undergraduate and graduate courses. The school has six departments with about 300 employees, located at AlbaNova University Center, Stockholm and Science for Life Laboratory, Solna. The biotechnology research within the school is internationally well recognized.

About Science for Life Laboratory

SciLifeLab is a national resource center dedicated to large scale bioscientific research with focus on biomedicine, including genome and proteome profiling, bioimaging and bioinformatics. SciLifeLab Stockholm has been formed jointly by the three Stockholm universities, Royal Institute of Technology (KTH), Karolinska Institutet (KI) and Stockholm University (SU), and thus combines the profiles and strengths of these three institutions. Academic research as well as the Swedish health care system and the Swedish Life Science industry will benefit through active collaboration, access to advanced tools and active programs for knowledge transfer. The goal is to achieve critical mass for large-scale life sciences and translational medicine.

Our vision is to make SciLifeLab into a center for large-scale life sciences with an advanced technological infrastructure. The focus is on performing multidisciplinary research involving high throughput DNA sequencing, analysis of gene expression, protein profiling, cellular profiling, advanced bioinformatics, biostatistics and systems biology. SciLifeLab is aimed at enabling researchers to carry out extensive and comprehensive analysis of genes, transcripts and proteins in humans and relevant microbes, such as viruses and bacteria, and to cast light on the complex interplay between different molecular components in living cells, tissues and organs related to human diseases.

Job description

A postdoctoral positions is available in the group of Statististical Biotechnology at Science for Life Laboratory (SciLifeLab) at the Royal Institute of Technology in Stockholm, Sweden. Our lab develops machine learning methods and statistical techniques for interpreting high-throughput experiments. We are looking for an enthusiastic and talented postdoctoral researcher to join our team. The postdoctoral position will involve interpretation of high-throughput biology data by machine learning and statistics. Depending on the interest of the applicant the position may be centered around either (1) Time-series analysis for meta-genomics data (2) Promoter analysis of DNA-methylation data from Type 2 Diabetes patients, or (3) Interpretation of mass spectrometry data.

The successful candidate will have a PhD in statistics, computer science, bioinformatics or related field with a strong quantitative component. Experience with machine learning techniques, GPU programming, and/or the handling large datasets is desirable.

Application

Application should be e-mailed to: rekr@biotech.kth.se

Deadline for application: 2013-11-01
Reference number: B-2013-0328

The application must include following documents:

a letter stating your research experience and interests,
a curriculum vitae including list of publications, and
name and contact information for yourself and two or three references.
Employment

Form of employment: Time-limited
Scope: Full-time
Salary: Salary is available as a one year scholarship with the possibility of renewal.
Start date: Negotiable
Announced positions: 1

Contact

Lukas Käll Associate professor
E-mail: Lukas.Kall@scilifelab.se

Union Representative

Lars Abrahamsson, SACO
Phone: +46 8-790 70 58
E-mail: lars.abrahamsson@ee.kth.se

http://www.kth.se/en/om/work-at-kth/vacancies/postdoctoral-research-fellow-in-computational-biology-at-scilifelab-stockholm-sweden-1.417129

Postdoctoral studies in Developmental Neuroimaging at Sweden

Postdoctoral studies in Developmental Neuroimaging

We announce a full-time post-doctoral position for two years with possibility of extension.

The successful candidate will work with the analysis and modeling of multimodal data from several studies of child development and cognitive training in children and young adults. The data consists of neuroimaging (fMRI, DTI, sMRI), behavioral and genetic measurements.

The work will be conducted at the Department of Neuroscience at the Karolinska Institute, Solna, Stockholm, which is a stimulating and international research environment (ki.se/neuroscience). The work will be co-supervised by Rita Almeida, statistician at the department for Neuroscience, and conducted in close association with the group for Developmental Cognitive Neuroscience (www.klingberglab.se) headed by Professor Torkel Klingberg.

Qualifications:

A desirable background is a PhD in cognitive neuroscience, including experience in neuroimaging and statistical image analysis as well as analysis of behavioral data. Experience in programing is valued (e.g. Matlab, Python) as well as knowledge of SPSS or R.

Application process
An application must contain the following documents in English:

1) Short cover letter describing interest in the position.

2) CV, including complete list of publications and degrees.

3) Contact information from three researchers willing to serve as reference persons.
The application is to be submitted on the NetRecruiter system.

Karolinska Institutet is one of the world´s leading medical
universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.

Closing date: 2013-06-20

Website: https://ki.netrecruiter.se/what:job/jobID:22715/where:4/

Postdoctoral Position in Cell biology 2013 Sweden

The impact of HDL and apolipoprotein A-I (main protein component of HDL) on glucose homeostasis has emerged, and both type 2 diabetes and insulin resistance are believed to be associated with reduced plasma concentrations of HDL particles.

Different mechanisms for HDL action on glucose metabolism has been suggested. Here, the postdoctor will apply TIRF and fluorescence microscopy for live cell imaging to investigate how glucose transporter (GLUT2 and GLUT4) are regulated by apolipoproteins in different adipose, muscle and beta-cell models. Also, general cell biology techniques are used to identify the molecular mechanisms involved in apo-induced insulin secretion and glucose uptake.

The projects are collaborations between groups within the Lund University Diabetes Centre (LUDC) working in the areas of clinical diabetes research and experimental cellbiology. The successful candidate will be part of the LUDC and is expected to stay updated on the research within the LUDC and to actively participate in common activities, e.g., to disseminate own results within the consortium and to assist other projects intellectually.

Requirements:

PhD degree, no earlier than three years before the date of advertisement (max 3 years). This period is extended correspondingsly by parental leave, clinical service, and certain commissions of trust. The candidate should be well-oriented within the diabetes research field. Significant experience and knowledge of fluorescence microscopy is essential. Experience with TIRF imaging and data processing is desirable. Some cell- and molecular biology training is required. The postdoctoral researcher is expected to conduct independent scientific work.

About us:

Lund University Diabetes Centre is one of 20 strong research programmes inSwedento be awarded the 10-year Linnaeus grant by the Swedish Research Council in 2006. The aim of LUDC is to identify strategies for slowing disease progression in diabetes and, ultimately, to prevent the disease. LUDC includes several research groups in Malmö andLundas well as several collaborators. The participating groups are all internationally renowned and form one of the strongest diabetes research environments world-wide. The position is situated at Biomedical Center, BMC,Lund.

Contact:

Karin Stenkula, Research Fellow

046-2227241

Karin.Stenkula@med.lu.se

Labour union

SACO: Lars-Åke Lööv

046-2228464

saco@saco.lu.se

OFR/S:LenaThiman

046-2229363

st@st.lu.se

For More Information

Postdoctoral position in biochemistry/ cell biology at Stockholm/ Sweden

Division Karolinska Institutet Alzheimer Disease Research Center (KI-ADRC) investigates Alzheimer disease and related disorders from different perspectives, emphasizing the integration of basic neuroscience, clinical research, molecular genetics and epidemiology.

Duties
Our research group is interested in identifying novel targets and biomarkers that may lead to improved therapeutic approaches to Alzheimer Disease and other dementias. We are looking for a highly motivated person that is well acquainted with basic biochemical and cell biological techniques. Previous experience from neuroscience, membrane proteins, protein labeling, protein interactions, mass spectrometry, glycobiology, assay development, confocal microscopy and cell culturing is meritorious.

Entry requirements
Scholarships to pursue postdoctoral studies may be awarded to individuals who come from other countries with the intention of remaining in Sweden only while obtaining all or part of their education. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher. Having received a salary or other remuneration from Karolinska Institutet during the past two years may be disqualifying. One requirement for receiving a scholarship for postdoctoral studies is central registration as a postdoc.

Type of scholarship
Karolinska Institutet awards scholarships to pursue postdoctoral studies. This educational scholarship, which is paid for a maximum of two years within seven years after the receipt of a PhD or the equivalent, is tax-exempt. The amount is set for a maximum of six months at a time and is paid out on a monthly basis.

Application process
An application must contain the following documents in English:
1. Curriculum vitae and qualifications, presented in accordance with Karolinska Institutet’s qualifications portfolio (http://ki.se/meritportfolj )
2. A complete list of publications
3. A summary of current work (no more than one page)
4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances
5. Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)
The application is to be submitted on the NetRecruiter system

Closing date: 2013-05-15

For More Information

Postdoc positon to study biomarkers of early Parkinson' s disease at Sweden 2013

Division Karolinska Institutet Alzheimer Disease Research Center (KI-ADRC) investigates Alzheimer disease and related disorders from different perspectives, emphasizing the integration of basic neuroscience, clinical research, molecular genetics and epidemiology.

Disorders of the brain are among the biggest challenges facing public and personal health today. Parkinson' s disease (PD) is a movement disorder in which there are protein aggregates in the brainstem and midbrain that affect multiple neurotransmitter systems, especially the dopaminergic. The next breakthrough in the treatment of PD would be to delay disease progression, based on insights into the underlying pathogenic process. The laboratory conducts both preclinical and clinical studies, both focusing on PD and Alzheimer’s disease. In clinical studies with patients, clinical evaluations, biochemical and imaging analyses are performed. A special emphasis is placed on the identification of biomarkers that reflect cognitive decline as neuroprotective and restorative therapy for PD shall be offered at an early stage to effectively change the course of the disease.

Duties
The overall objective of the current project is to develop a prognostic biomarker algorithm combining CSF and PET data to identify pre-motor and early PD as well as PD patients at risk for early and rapid cognitive decline.

Over the course of the postdoctoral appointment, the candidate will develop different biomarker assays, especially in cerebrospinal fluid, for studies of proteins involved in neurodegenerative processes of the brain. The candidate is expected to generate data that can be used as predictive biomarkers of disease progression for cognitive decline in PD. Independence and strong motivation are expected throughout the project.

Entry requirements
A person is eligible for a postdoc position if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc.

As a person, the candidate should be flexible, communicative and collaborative and being comfortable with having parallel activities. The main activities will be characterization of biochemical biomarkers followed by the development and validation of quantitative immunoassays. Candidates will be encouraged to serve as mentors for exam students and co-mentors for Ph.D. students, thus building their experience for future leadership. The project is funded by Astra Zeneca, so good interpersonal skills with an industrial partner are critical

Closing date: 2013-05-08

For More Information

Industrial Postdoc Position in drug discovery at AstraZeneca, Sweden

Location: Mölndal, Sweden

AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

Right now we have an exciting opportunity for a Ph.D. scientist to develop methodology that determines the orientation of ligands bound to proteins of pharmaceutical interest. The aim of the work is to produce information that is complementary to conventional methods for structure determination of protein-ligand complexes and enable more efficient synthetic chemistry efforts in a drug discovery programme. The work is multi-disciplinary in nature and includes secondments to Leiden University and the University of Florence, research centres with extensive experience in paramagnetic protein NMR.

This position is part of the FP7 – PEOPLE Marie Curie Initial Training Network "pNMR" (Pushing the Envelope of Nuclear Magnetic Resonance Spectroscopy for Paramagnetic Systems. A Combined Experimental and Theoretical Approach). For more information please visit http://www.pnmr.eu/.

Objectives
• To enable more efficient synthetic chemistry efforts in drug discovery by determining the relative orientation of small molecule ligands to at least one drug target protein.
• To show that this can be achieved within a time-frame that is compatible with the time-lines in a drug-discovery programme.

Responsibilities
• Show strong initiative in conducting research, and bringing it to functional use within AstraZeneca and the drug discovery community.
• Interface with scientists from across many disciplines while at the same time being able to work independently.
• Strong written and oral communication skills.
• Ability to work effectively with colleagues and initiate collaboration.

Tasks and methodology
• Production of drug target protein with lanthanide binding tags rigidly attached.
• Determination of pseudo-contact shift (PCS) tensors for the lanthanide tagged proteins.
• Detection of transferred PCSs for several ligands.
• Structure calculations based on PCSs. Comparison with known crystal structures to assess quality of PCS-based structures.

Minimum experience
• A PhD in biomolecular NMR or closely related field.

Preferred experience/requirements
• Protein NMR assignments.
• Protein-ligand interactions and binding kinetics.
• Protein production.
• Paramagnetic NMR.
• Synthetic chemistry.

AstraZeneca – Health Connects Us All
As one of the world's leading pharmaceutical companies, our business is focused on providing innovative, effective medicines that make a real difference in important areas of healthcare. What’s more, we support and encourage our people in discovering their own potential. Excellent learning and development opportunities will be available to you throughout your career here.

Contact:
For more information about the position please contact Tomas Åkerud at +46 31 7064412

Please send your application no later than April 30, 2013

AstraZeneca welcomes applications from all sections of the community.

http://jobs.astrazeneca.com/jobs