Post-Doctoral researchers position in the frame of an ERC funded program 2013 France

Antoine Triller’s research group is seeking to recruit 3 Post-Doctoral researchers in the frame of an ERC funded program.
For further information see: http://www.ibens.ens.fr/?lang=en.
For questions please contact Christian Specht: specht@biologie.ens.fr

Applications should include a cover letter, a Curriculum Vitae and two letters of recommendation e-mailed directly by their authors to:
daniele.murciano@ens.fr
christian.specht@ens.fr

DEADLINE FOR APPLICATIONS MAY 15th, 2013.
Start date: End of 2013 at the latest.

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Post-doctoral Marie Curie fellowship - Neuroscience 2013

We are looking for a PhD willing to apply for a post-doctoral Marie Curie fellowship to work with us, in the Institut des Maladies Neurodégénératives (IMN) for the next 2-3 years.

The study is to compare the properties of cortico-subthalamic vs thalamo-subthalamic synapses. We will use patch clamping in brain slices and optogenetics. We already have preliminary results on the basic properties of glutamatergic synapses in the STN using electrical stimulations of the afferent fibers, and also on that of cortico-subthlamic synapses using optical stimulations of ChR2-expressing afferent fibers. The postulant will have i) to implement the transfection of the parafascicular nucleus of the thalamus using stereotaxy ii) decipher the properties of thalamo-subthalamic synapses in vitro iii) examine how subthalamic neurons integrate the synaptic messages from cortex and thalamus.

People with either experience in either in vitro electrophysiology or in vivo recordings + stereotaxy will be welcome.

Marie Curie fellowship (FP7-PEOPLE-2013-CIG) are specific in several aspects, one being that the proposal must to be jointly submitted by the applicant host organisation (i.e. team leader + lab leader + University) and the candidate. Another specificity comes from the eligibility rules.
Contact Information
Dr Taupignon Anne
Institut des Maladies Neurodégénératives
Synaptic and Cellular Dynamics of Neuronal Networks
148 rue Leo Saignat
33076 Bordeaux
France
Phone:     (0033)557575764
Fax:     (0033)557575760
E-mail:     anne.taupignon@u-bordeaux2.fr

Closing date: 2013-05-31

For More Information and to apply

Cellular neuroscience Postdoctoral scientist position 2013 - France

We seek to hire a highly motivated postdoctoral scientist to work on AMPA receptor dynamics and synaptic plasticity in basal ganglia brain slices using a combination of advanced imaging and electrophysiology approaches (receptor diffusion imaging; receptors cross-linking; electrophysiology in acute brain slices). This project is oriented towards the understanding of the contribution of AMPA receptor dynamics in the functioning of subthalamo-nigral glutamatergic synapses and its eventual participation to the beneficial effects of deep brain stimulation in alleviating Parkinson’s disease motor symtoms.

The candidate should have a strong background/interest in cellular neuroscience / imaging / electrophysiology. S/he will work in a highly interdisciplinary research environment, including neurobiologists and microscopy developers.

The project brings together the teams of Jérôme baufreton and Daniel Choquet, with excellent track records in synaptic plasticity and AMPA receptor dynamics. The position is funded for one year and can be renewed for an additional one or two years.

The Bordeaux Neuroscience Institute is a leading European neuroscience research center with outstanding infrastructural support and interaction partners, particularly in cellular neuroscience and synaptic plasticity.

Please send a CV and a brief statement of research experience to:
Bernard.bioulac@u-bordeaux2.fr

Contact Information
Pr Bernard Bioulac
UMR CNRS 5293
Institut des Maladies Neurodégénératives
146, rue Léo saignat
33076 Bordeaux
France
Phone:     +33 5 57 57 15 49
Fax:     +33 5 57 57 57 60
E-mail:     bernard.bioulac@u-bordeaux2.fr

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Molecular Biomarkers - Postdoctoral position 2013 France

High-throughput "omic" technologies represent promising opportunities to find new disease biomarkers because of their comprehensiveness and their complementarity. However, integration of such massive and highly heterogeneous data is a bioinformatic challenge. First, for each experiment, raw data must be processed to obtain a n sample x p variable table of signal intensities (e.g. peak detection, quality control, normalization). Second, innovative statistical methods must be developed to extract relevant features from those n << p matrices. Third, additional database information regarding interactions between molecules must be taken into account in collaboration with biologists to validate the identified biomarkers and fingerprints.

Project:

The Biomargin European project aims at finding new molecular biomarkers of renal graft injuries and at developing algorithms to assist clinicians in detecting and interpreting chronic graft dysfunction. As leader of the workpackage "Data integration and disease prediction modeling", our team will first be responsible for statistical integration of the datasets (transcriptomic, proteomic and metabolomic) provided by the clinical partners. Second, the annotated candidate biomarkers will be validated through pathway analysis (e.g. with the Ingenuity software). Third, a model of disease progression based on the selected fingerprints will be developed and validated on a prospective cohort of transplant patients.

Job description:

In our laboratory, the post holder will use multivariate statistical techniques (multi-block analysis, orthogonal partial least-squares) for data integration and biomarker selection. All information regarding the selected molecules will be stored in a dedicated database. Once the candidate markers have been validated by the experimental partners, machine learning algorithms will be developed for the prediction of patient status.

 Profile:

 Interested applicants should hold a PhD in biostatistics or bioinformatics and and be used to programming with the R software. The candidate should be highly motivated by applied trans disciplinary team work aiming at clinical applications.
 
Our offer:

    1-year contract (renewable once).

    Net salary: about 2200 €/month, depending on experience.

Note:

    Funding is dedicated to PhD candidates under 30 years old.

To apply

    Please send your CV and your letter of motivation to:
    Etienne Thévenot (etienne.thevenot@cea.fr)
    Laboratory of Data Analysis Tools
    CEA Saclay, F-91191 Gif-sur-Yvette, France

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Computational biology Postdoctoral Position 2013 - France

    Employer:INSERM (Institut National de la Santé et de la Recherche Médicale)
    Location: Paris, France
    Compensation: to negotiate; relocation allowance to be discussed
    Job Type : Contract, promotion to a permanent position possible
    Term of Position: 24 months, promotion to a permanent position to be discussed
    Posted: April 3, 2013
    Application Deadline : Open until filled

    Description:

    We are looking for a candidate with strong Machine Learning background to join the Nutriomics team. The laboratory is associated with the INSERM (National French Institute of Medicine and Health), University Pierre et Marie Curie, and ICAN ( Institute of Cardiometabolism and Nutrition).

    About the position:

    Candidates should have a good background in probabilistic graphical models, statistical learning, and Bayesian inference (generative/discriminative setting). PhD degree in mathematical, computer modeling, bioinformatics/biostatistics, or related science.

    Experience in analyzing large volumes of data is good to have.

    Interest in biology. Background in computational biology and experience with biological datasets are desirable but not obligatory.

    Good spoken and written English, excellent communication skills, mature and motivated, as well as a pro-active attitude, creative and multitasking.

    Experience in developing tools or packages in R, Maltlab, etc. is expected.

    About the Nutriomics team:

    The Nutriomics team is focused on understanding of the patho-physiological mechanisms associated with obesity at its different stages of natural evolution. We are studying mechanisms of regulation in response to environmental variations and changes, and we are interested in integration of complex clinical and biological data.
To apply

    Applicants should email to Prof. Jean-Daniel Zucker and Prof. Karine Clement at Recruitment@fondation-ican.com with subject line “Postdoc application” and include a cover letter, a CV, and a list of at least two references.

France: post-doctoral position developmental neurobiology at The Institute of Neurosciences of Montpellier

"The Institute of Neurosciences of Montpellier (INM) is a research centre dedicated to the study of the physiopathology of sensory (audition, vision, somatosensation) and motor systems by a multidisciplinary strategy (molecular genetics, cellular imaging, electrophysiology, and in vivo analyses). Interests range from basic research to preclinical studies leading to the development of novel therapeutic approaches to treating dysfunctions of these systems.
A 2-year post-doctoral position is available to carry out a project to study the fundamental question of how sensory neurons transducing touch connect with their synaptic partners in the spinal cord. In previous work, we have shown that transcription factors of the Maf family and the Ret signalling pathway play essential roles in the development of mechanosensory neurons of the sensory ganglia. Recently, we identified a cell adhesion molecule whose expression in touch-sensing neurons depends on cMaf. Our objective is to analyse the function of this adhesion molecule in the formation of cutaneous projections and of touch neuron/spinal interneuron connectivity by studying mice in which the gene is conditionally deleted in somatosensory neurons and/or their spinal target neurons. We are looking for a highly-motivated candidate with a strong interest in developmental neurobiology. Experience in cell biological techniques such as cell and explant culture and tracing of axonal projections would be an advantage."


Contact Information
Dr. Patrick Carroll
INSERM U.1051
Neural differentiation and connectivity in the somatosensory system
rue Augustion Fliche
34091 Montpellier
France
Phone:     (33) 4 99636041
Fax:     (33) 4 99636020
E-mail:     carroll@univ-montp2.fr
Website:     http://www.inmfrance.com/1_equipe3_Carroll.php

Closing date: 2013-06-01

France: Postdoc position in molecular genetics at ICM

Postdoctoral fellow to join Dr. Kabashi’s group in the newly opened -ICM - Institut du Cerveau et de la Moelle épinière at the renowned Hospital Pitié-Salpêtrière located in Paris, France.
Duration: 1-2 years

Project description

• To functionally characterize novel mutations identified in a panel of neurodegenerative diseases, ranging from frontotemporal dementia (FTD), and spastic paraplegia (SPG), to amyotrophic lateral sclerosis (ALS).
• These studies will involve developing in vitro (cell lines and primary neuronal cultures) as well as in vivo (zebrafish) models. Both overexpression of these mutant genes and/or knockdown/knockout of the genes will be performed in these models. To study degeneration of subset of neurons in the brain and spinal cord, an array of molecular biology techniques will be used.
• Techniques used:
• Molecular genetics: Latest human and animal molecular genetic techniques
• Molecular biology: DNA cloning, PCR, site directed mutagenesis, in situ hybridization.
• Biochemistry: protein purification, immunoprecipitation, pull-down and Western blotting.
• Zebrafish genetics: Microinjection of RNA and antisense morpholino oligonucleotides. Generation and maintenance of transgenic zebrafish lines.
• Immunohistochemistry and live imaging of zebrafish embryos. Behavioral assays and electrophysiological recordings

Research experience:

• PhD in life or health sciences. Experience in molecular genetics a must.
• Candidates with extensive experience on disease-related animal models are encouraged to apply.
• Strong background in cellular and molecular biology, genetics, and/ biochemistry.
• Motivated and enthusiastic candidate
• Willing to learn and establish novel techniques in the lab
• Good team spirit and work well in collaboration

In order to apply please send your CV, two references and a letter of recommendation to:
Dr. Edor Kabashi: edor.kabashi@icm-institute.org"

France: Postdoc position in Neurosciences at GRAP INSERM ERI24

"One major predicting factors of adult alcohol addiction is the age of the first experience with alcohol. Today, young people are drinking alcohol early in life, heavily and rapidly, alternating with abstinence periods; the so-called “binge-drinking” characterized by high level of alcohol intoxication, drunkenness and possibly ethylic coma. Alcohol disturbs cognitive functions such as learning and memory and the hippocampus of young people is highly sensitive regarding the effects of alcohol on synaptic plasticity, the cellular mechanism of memory. However, we do not know the exact cellular and molecular mechanisms affected by alcohol when consumed in a binge-drinking pattern.
We developed animal models of binge-drinking in rat and showed that alcohol exposure during adolescence increase motivation to drink alcohol at adult age (Alaux-Cantin S et al 2012), suggesting that binge-drinking did change brain functioning on the long-term. We also recently found that bidirectional synaptic plasticity in the hippocampus was differentially affected by a binge-like pattern of alcohol intoxication and that some of the effects are delayed, suggesting developing deleterious mechanisms during the ‘withdrawal’ period when blood alcohol levels returned to zero. We wish now to better understand at cellular level the effects of alcohol in the hippocampus by measuring its effects on both NMDA and GABA receptors function during synaptic plasticity. Molecular mechanisms will be addressed with pharmacology and molecular biology. Learning performances will be tested in an 8-arms radial maze. For this purpose, we sought a highly motivated candidate for a post-doc position. This candidate should have a PhD in Neurosciences with a great experience in patch-clamp recordings on acute slice. Personal autonomy with the recording set-up and computerized method of analysis is compulsory to the position. Experience in the field of drug addiction would be a plus but is not obligatory."

Closing date:       -the deadline is not set

Contact Information
Pr Pierrefiche Olivier
INSERM ERi 24 GRAP
Pharmacy
1 rue des Louvels
80110 Amiens
France
Phone:    
Fax:    
E-mail:     olivier.pierrefiche@u-picardie.fr
Website:     http://www.u-picardie.fr/decouverte/sante/pagesliees/grap/accueilgrap.html